2cyf

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
m (Protected "2cyf" [edit=sysop:move=sysop])
Line 1: Line 1:
-
[[Image:2cyf.png|left|200px]]
+
==The Crystal Structure of Canavalia Maritima Lectin (ConM) in Complex with Trehalose and Maltose==
 +
<StructureSection load='2cyf' size='340' side='right' caption='[[2cyf]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
 +
== Structural highlights ==
 +
<table><tr><td colspan='2'>[[2cyf]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Canavalia_rosea Canavalia rosea]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CYF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CYF FirstGlance]. <br>
 +
</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MAL:MALTOSE'>MAL</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene><br>
 +
<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2cwm|2cwm]], [[2cy6|2cy6]]</td></tr>
 +
<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2cyf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cyf OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2cyf RCSB], [http://www.ebi.ac.uk/pdbsum/2cyf PDBsum]</span></td></tr>
 +
<table>
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cy/2cyf_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
 +
<div style="clear:both"></div>
 +
<div style="background-color:#fffaf0;">
 +
== Publication Abstract from PubMed ==
 +
The crystal structure of Canavalia maritima lectin (ConM) complexed with trehalose and maltose revealed relevant point mutations in ConA-like lectins. ConM with the disaccharides and other ConA-like lectins complexed with carbohydrates demonstrated significant differences in the position of H-bonds. The main difference in the ConM structure is the replacement of Pro202 by Ser202, a residue that promotes the approximation of Tyr12 to the carbohydrate-binding site. The O-6' of the second glucose ring in maltose interacts with Tyr12, while in trehalose the interaction is established by the O-2' and Tyr12, explaining the higher affinity of ConM for disaccharides compared to monosaccharides.
-
{{STRUCTURE_2cyf| PDB=2cyf | SCENE= }}
+
Crystal structure of a lectin from Canavalia maritima (ConM) in complex with trehalose and maltose reveals relevant mutation in ConA-like lectins.,Delatorre P, Rocha BA, Gadelha CA, Santi-Gadelha T, Cajazeiras JB, Souza EP, Nascimento KS, Freire VN, Sampaio AH, Azevedo WF Jr, Cavada BS J Struct Biol. 2006 Jun;154(3):280-6. Epub 2006 Apr 21. PMID:16677825<ref>PMID:16677825</ref>
-
===The Crystal Structure of Canavalia Maritima Lectin (ConM) in Complex with Trehalose and Maltose===
+
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
 +
</div>
-
{{ABSTRACT_PUBMED_16677825}}
+
==See Also==
-
 
+
*[[Concanavalin A|Concanavalin A]]
-
==About this Structure==
+
== References ==
-
[[2cyf]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Canavalia_rosea Canavalia rosea]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CYF OCA].
+
<references/>
-
 
+
__TOC__
-
==Reference==
+
</StructureSection>
-
<ref group="xtra">PMID:016677825</ref><references group="xtra"/>
+
[[Category: Canavalia rosea]]
[[Category: Canavalia rosea]]
[[Category: Azevedo, W F.]]
[[Category: Azevedo, W F.]]

Revision as of 00:05, 30 September 2014

The Crystal Structure of Canavalia Maritima Lectin (ConM) in Complex with Trehalose and Maltose

2cyf, resolution 1.80Å

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2cyf"
Views
Personal tools
Navigation
Toolbox