1hmy
From Proteopedia
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| - | [[Image:1hmy.jpg|left|200px]] | + | [[Image:1hmy.jpg|left|200px]] |
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| - | '''CRYSTAL STRUCTURE OF THE HHAL DNA METHYLTRANSFERASE COMPLEXED WITH S-ADENOSYL-L-METHIONINE''' | + | {{Structure |
| + | |PDB= 1hmy |SIZE=350|CAPTION= <scene name='initialview01'>1hmy</scene>, resolution 2.5Å | ||
| + | |SITE= | ||
| + | |LIGAND= <scene name='pdbligand=SAM:S-ADENOSYLMETHIONINE'>SAM</scene> | ||
| + | |ACTIVITY= [http://en.wikipedia.org/wiki/DNA_(cytosine-5-)-methyltransferase DNA (cytosine-5-)-methyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.37 2.1.1.37] | ||
| + | |GENE= | ||
| + | }} | ||
| + | |||
| + | '''CRYSTAL STRUCTURE OF THE HHAL DNA METHYLTRANSFERASE COMPLEXED WITH S-ADENOSYL-L-METHIONINE''' | ||
| + | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1HMY is a [ | + | 1HMY is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Haemophilus_haemolyticus Haemophilus haemolyticus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HMY OCA]. |
==Reference== | ==Reference== | ||
| - | Crystal structure of the HhaI DNA methyltransferase complexed with S-adenosyl-L-methionine., Cheng X, Kumar S, Posfai J, Pflugrath JW, Roberts RJ, Cell. 1993 Jul 30;74(2):299-307. PMID:[http:// | + | Crystal structure of the HhaI DNA methyltransferase complexed with S-adenosyl-L-methionine., Cheng X, Kumar S, Posfai J, Pflugrath JW, Roberts RJ, Cell. 1993 Jul 30;74(2):299-307. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/8343957 8343957] |
[[Category: DNA (cytosine-5-)-methyltransferase]] | [[Category: DNA (cytosine-5-)-methyltransferase]] | ||
[[Category: Haemophilus haemolyticus]] | [[Category: Haemophilus haemolyticus]] | ||
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[[Category: transferase(methyltransferase)]] | [[Category: transferase(methyltransferase)]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 11:39:07 2008'' |
Revision as of 09:39, 20 March 2008
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| , resolution 2.5Å | |||||||
|---|---|---|---|---|---|---|---|
| Ligands: | |||||||
| Activity: | DNA (cytosine-5-)-methyltransferase, with EC number 2.1.1.37 | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
CRYSTAL STRUCTURE OF THE HHAL DNA METHYLTRANSFERASE COMPLEXED WITH S-ADENOSYL-L-METHIONINE
Overview
The first three-dimensional structure of a DNA methyltransferase is presented. The crystal structure of the DNA (cytosine-5)-methyltransferase, M.HhaI (recognition sequence: GCGC), complexed with S-adenosyl-L-methionine has been determined and refined at 2.5 A resolution. The core of the structure is dominated by sequence motifs conserved among all DNA (cytosine-5)-methyltransferases, and these are responsible for cofactor binding and methyltransferase function.
About this Structure
1HMY is a Single protein structure of sequence from Haemophilus haemolyticus. Full crystallographic information is available from OCA.
Reference
Crystal structure of the HhaI DNA methyltransferase complexed with S-adenosyl-L-methionine., Cheng X, Kumar S, Posfai J, Pflugrath JW, Roberts RJ, Cell. 1993 Jul 30;74(2):299-307. PMID:8343957
Page seeded by OCA on Thu Mar 20 11:39:07 2008
