2bab

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[[Image:2bab.png|left|200px]]
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==Crystal structure of CLA-producing fatty acid isomerase from P. acnes==
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<StructureSection load='2bab' size='340' side='right' caption='[[2bab]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2bab]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Propionibacterium_acnes Propionibacterium acnes]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BAB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2BAB FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BU1:1,4-BUTANEDIOL'>BU1</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=ODD:(10E,12Z)-OCTADECA-10,12-DIENOIC+ACID'>ODD</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene><br>
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<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2b9w|2b9w]], [[2b9x|2b9x]], [[2b9y|2b9y]], [[2ba9|2ba9]], [[2bac|2bac]]</td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2bab FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bab OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2bab RCSB], [http://www.ebi.ac.uk/pdbsum/2bab PDBsum]</span></td></tr>
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<table>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ba/2bab_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Conjugated linoleic acids (CLAs) affect body fat gain, carcinogenesis, insulin resistance, and lipid peroxidation in mammals. Several isomers of CLA exist, of which the (9Z, 11E) and (10E, 12Z) isomers have beneficial effects on human metabolism but are scarce in foods. Bacterial polyunsaturated fatty acid isomerases are promising biotechnological catalysts for CLA production. We describe six crystal structures of the Propionibacterium acnes polyunsaturated fatty acid isomerase PAI in apo- and product-bound forms. The three-domain flavoprotein has previously undescribed folds outside the FAD-binding site. Conformational changes in a hydrophobic channel toward the active site reveal a unique gating mechanism for substrate specificity. The geometry of the substrate-binding site explains the length preferences for C18 fatty acids. A catalytic mechanism for double-bond isomerization is formulated that may be altered to change substrate specificity for syntheses of rare CLAs from easily accessible precursors.
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{{STRUCTURE_2bab| PDB=2bab | SCENE= }}
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Structure and mechanism of the Propionibacterium acnes polyunsaturated fatty acid isomerase.,Liavonchanka A, Hornung E, Feussner I, Rudolph MG Proc Natl Acad Sci U S A. 2006 Feb 21;103(8):2576-81. Epub 2006 Feb 13. PMID:16477020<ref>PMID:16477020</ref>
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===Crystal structure of CLA-producing fatty acid isomerase from P. acnes===
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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{{ABSTRACT_PUBMED_16477020}}
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== References ==
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<references/>
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==About this Structure==
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__TOC__
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[[2bab]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Propionibacterium_acnes Propionibacterium acnes]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BAB OCA].
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</StructureSection>
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==Reference==
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<ref group="xtra">PMID:016477020</ref><references group="xtra"/>
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[[Category: Propionibacterium acnes]]
[[Category: Propionibacterium acnes]]
[[Category: Liavonchanka, A.]]
[[Category: Liavonchanka, A.]]

Revision as of 00:33, 30 September 2014

Crystal structure of CLA-producing fatty acid isomerase from P. acnes

2bab, resolution 2.00Å

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