2e5r
From Proteopedia
(Difference between revisions)
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| - | + | ==Solution structure of the ZZ domain of Dystrobrevin alpha (Dystrobrevin-alpha)== | |
| - | + | <StructureSection load='2e5r' size='340' side='right' caption='[[2e5r]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''> | |
| - | + | == Structural highlights == | |
| - | ==Disease== | + | <table><tr><td colspan='2'>[[2e5r]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2E5R OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2E5R FirstGlance]. <br> |
| - | [[http://www.uniprot.org/uniprot/DTNA_HUMAN DTNA_HUMAN]] Defects in DTNA are the cause of left ventricular non-compaction type 1 (LVNC1) [MIM:[http://omim.org/entry/604169 604169]]. Left ventricular non-compaction is due to an arrest of myocardial morphogenesis. The disorder is characterized by a hypertrophic left ventricle with deep trabeculations and with poor systolic function, with or without associated left ventricular dilation. In some cases, it is associated with other congenital heart anomalies such as ventricular septal defects, pulmonic stenosis and atrial septal defects. The right ventricle may also be affected.<ref>PMID:11238270</ref> | + | </td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene><br> |
| - | + | <tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">DTNA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr> | |
| - | ==Function== | + | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2e5r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2e5r OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2e5r RCSB], [http://www.ebi.ac.uk/pdbsum/2e5r PDBsum], [http://www.topsan.org/Proteins/RSGI/2e5r TOPSAN]</span></td></tr> |
| + | <table> | ||
| + | == Disease == | ||
| + | [[http://www.uniprot.org/uniprot/DTNA_HUMAN DTNA_HUMAN]] Defects in DTNA are the cause of left ventricular non-compaction type 1 (LVNC1) [MIM:[http://omim.org/entry/604169 604169]]. Left ventricular non-compaction is due to an arrest of myocardial morphogenesis. The disorder is characterized by a hypertrophic left ventricle with deep trabeculations and with poor systolic function, with or without associated left ventricular dilation. In some cases, it is associated with other congenital heart anomalies such as ventricular septal defects, pulmonic stenosis and atrial septal defects. The right ventricle may also be affected.<ref>PMID:11238270</ref> | ||
| + | == Function == | ||
[[http://www.uniprot.org/uniprot/DTNA_HUMAN DTNA_HUMAN]] May be involved in the formation and stability of synapses as well as being involved in the clustering of nicotinic acetylcholine receptors. | [[http://www.uniprot.org/uniprot/DTNA_HUMAN DTNA_HUMAN]] May be involved in the formation and stability of synapses as well as being involved in the clustering of nicotinic acetylcholine receptors. | ||
| - | + | == Evolutionary Conservation == | |
| - | == | + | [[Image:Consurf_key_small.gif|200px|right]] |
| - | [[ | + | Check<jmol> |
| - | + | <jmolCheckbox> | |
| - | == | + | <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/e5/2e5r_consurf.spt"</scriptWhenChecked> |
| - | <references | + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> |
| + | <text>to colour the structure by Evolutionary Conservation</text> | ||
| + | </jmolCheckbox> | ||
| + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf]. | ||
| + | <div style="clear:both"></div> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Dang, W.]] | [[Category: Dang, W.]] | ||
Revision as of 00:34, 30 September 2014
Solution structure of the ZZ domain of Dystrobrevin alpha (Dystrobrevin-alpha)
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Categories: Homo sapiens | Dang, W. | Inoue, M. | Kigawa, T. | Muto, Y. | RSGI, RIKEN Structural Genomics/Proteomics Initiative. | Shirouzu, M. | Terada, T. | Yokoyama, S. | Dna binding protein | Dystrobrevin alpha | Dystrobrevin-alpha | National project on protein structural and functional analyse | Nppsfa | Riken structural genomics/proteomics initiative | Rsgi | Structural genomic | Zz domain
