1hqz

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[[Image:1hqz.gif|left|200px]]<br /><applet load="1hqz" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:1hqz.gif|left|200px]]
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caption="1hqz, resolution 2.10&Aring;" />
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'''Cofilin homology domain of a yeast actin-binding protein ABP1P'''<br />
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{{Structure
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|PDB= 1hqz |SIZE=350|CAPTION= <scene name='initialview01'>1hqz</scene>, resolution 2.10&Aring;
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|SITE=
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|LIGAND=
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|ACTIVITY=
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|GENE=
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}}
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'''Cofilin homology domain of a yeast actin-binding protein ABP1P'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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1HQZ is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HQZ OCA].
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1HQZ is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HQZ OCA].
==Reference==
==Reference==
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Phased translation function revisited: structure solution of the cofilin-homology domain from yeast actin-binding protein 1 using six-dimensional searches., Strokopytov BV, Fedorov A, Mahoney NM, Kessels M, Drubin DG, Almo SC, Acta Crystallogr D Biol Crystallogr. 2005 Mar;61(Pt 3):285-93. Epub 2005, Feb 24. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=15735338 15735338]
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Phased translation function revisited: structure solution of the cofilin-homology domain from yeast actin-binding protein 1 using six-dimensional searches., Strokopytov BV, Fedorov A, Mahoney NM, Kessels M, Drubin DG, Almo SC, Acta Crystallogr D Biol Crystallogr. 2005 Mar;61(Pt 3):285-93. Epub 2005, Feb 24. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15735338 15735338]
[[Category: Saccharomyces cerevisiae]]
[[Category: Saccharomyces cerevisiae]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: protein structure initiative]]
[[Category: protein structure initiative]]
[[Category: psi]]
[[Category: psi]]
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[[Category: structural genomics]]
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[[Category: structural genomic]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 13:04:11 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 11:40:31 2008''

Revision as of 09:40, 20 March 2008

Image:1hqz.gif


PDB ID 1hqz

Drag the structure with the mouse to rotate
, resolution 2.10Å
Coordinates: save as pdb, mmCIF, xml



Cofilin homology domain of a yeast actin-binding protein ABP1P


Overview

A modified molecular-replacement method is described that makes use of six-dimensional searches and the phased translation function, providing a systematic examination of all possible search-model orientations in an experimental electron-density map. As an example, the structure solution of the cofilin-homology domain of the Saccharomyces cerevisiae actin-binding protein 1 (ABP1) is presented in detail. Additional examples are presented in which these tools have significantly aided structure solutions in a variety of contexts. These results suggest that this approach might be of widespread utility for challenging structures involving weak phase information, complex asymmetric units and search models with weak structural homology. Furthermore, this approach supports an exhaustive molecular-replacement strategy in cases where an appropriate search model cannot readily be identified on the basis of sequence homology. The fully automated web-based implementation of this phased translation function is described.

About this Structure

1HQZ is a Single protein structure of sequence from Saccharomyces cerevisiae. Full crystallographic information is available from OCA.

Reference

Phased translation function revisited: structure solution of the cofilin-homology domain from yeast actin-binding protein 1 using six-dimensional searches., Strokopytov BV, Fedorov A, Mahoney NM, Kessels M, Drubin DG, Almo SC, Acta Crystallogr D Biol Crystallogr. 2005 Mar;61(Pt 3):285-93. Epub 2005, Feb 24. PMID:15735338

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