1hrn

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[[Image:1hrn.gif|left|200px]]<br /><applet load="1hrn" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:1hrn.gif|left|200px]]
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caption="1hrn, resolution 1.8&Aring;" />
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'''HIGH RESOLUTION CRYSTAL STRUCTURES OF RECOMBINANT HUMAN RENIN IN COMPLEX WITH POLYHYDROXYMONOAMIDE INHIBITORS'''<br />
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{{Structure
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|PDB= 1hrn |SIZE=350|CAPTION= <scene name='initialview01'>1hrn</scene>, resolution 1.8&Aring;
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|SITE=
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|LIGAND= <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=PPP:3-PHENYL-1,2-PROPANDIOL'>PPP</scene>, <scene name='pdbligand=CPP:2-CYCLOPROPYLMETHYLENEPROPANAL'>CPP</scene> and <scene name='pdbligand=IP3:1-HYDROXY-3-METHYLBUTANE'>IP3</scene>
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|ACTIVITY=
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|GENE=
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}}
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'''HIGH RESOLUTION CRYSTAL STRUCTURES OF RECOMBINANT HUMAN RENIN IN COMPLEX WITH POLYHYDROXYMONOAMIDE INHIBITORS'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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1HRN is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=NAG:'>NAG</scene>, <scene name='pdbligand=PPP:'>PPP</scene>, <scene name='pdbligand=CPP:'>CPP</scene> and <scene name='pdbligand=IP3:'>IP3</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. The following page contains interesting information on the relation of 1HRN with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb12_1.html Pepsin]]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HRN OCA].
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1HRN is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. The following page contains interesting information on the relation of 1HRN with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb12_1.html Pepsin]]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HRN OCA].
==Reference==
==Reference==
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High resolution crystal structures of recombinant human renin in complex with polyhydroxymonoamide inhibitors., Tong L, Pav S, Lamarre D, Pilote L, LaPlante S, Anderson PC, Jung G, J Mol Biol. 1995 Jul 7;250(2):211-22. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=7608971 7608971]
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High resolution crystal structures of recombinant human renin in complex with polyhydroxymonoamide inhibitors., Tong L, Pav S, Lamarre D, Pilote L, LaPlante S, Anderson PC, Jung G, J Mol Biol. 1995 Jul 7;250(2):211-22. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/7608971 7608971]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Pepsin]]
[[Category: Pepsin]]
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[[Category: aspartic proteinase]]
[[Category: aspartic proteinase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 13:04:10 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 11:40:46 2008''

Revision as of 09:40, 20 March 2008

Image:1hrn.gif


PDB ID 1hrn

Drag the structure with the mouse to rotate
, resolution 1.8Å
Ligands: , , and
Coordinates: save as pdb, mmCIF, xml



HIGH RESOLUTION CRYSTAL STRUCTURES OF RECOMBINANT HUMAN RENIN IN COMPLEX WITH POLYHYDROXYMONOAMIDE INHIBITORS


Contents

Overview

The crystal structures of recombinant glycosylated human renin in complex with several polyhydroxymonoamide inhibitors have been determined at up to 1.8 A resolution. The high resolution structures permit a detailed analysis of the conformation of renin, the interactions between the inhibitors and renin, and the network of ordered water molecules. The polyhydroxymonoamide inhibitors are bound with their backbones in an extended conformation, and with their side-chains occupying the S3 to S1 pockets. The inhibited renin molecules are shown to exist in both the closed and the open conformations. Inhibitors bound to the two distinct forms of renin can assume different conformations at the P3 position.

Disease

Known diseases associated with this structure: Hyperproreninemia OMIM:[179820], Renal tubular dysgenesis OMIM:[179820]

About this Structure

1HRN is a Single protein structure of sequence from Homo sapiens. The following page contains interesting information on the relation of 1HRN with [Pepsin]. Full crystallographic information is available from OCA.

Reference

High resolution crystal structures of recombinant human renin in complex with polyhydroxymonoamide inhibitors., Tong L, Pav S, Lamarre D, Pilote L, LaPlante S, Anderson PC, Jung G, J Mol Biol. 1995 Jul 7;250(2):211-22. PMID:7608971

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