1hsr

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[[Image:1hsr.gif|left|200px]]<br /><applet load="1hsr" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:1hsr.gif|left|200px]]
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caption="1hsr, resolution 1.60&Aring;" />
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'''BINDING MODE OF BENZHYDROXAMIC ACID TO ARTHROMYCES RAMOSUS PEROXIDASE'''<br />
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{{Structure
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|PDB= 1hsr |SIZE=350|CAPTION= <scene name='initialview01'>1hsr</scene>, resolution 1.60&Aring;
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|SITE= <scene name='pdbsite=CA1:Active+Site'>CA1</scene>, <scene name='pdbsite=CA2:Active+Site'>CA2</scene> and <scene name='pdbsite=GL1:Active+Site'>GL1</scene>
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|LIGAND= <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene> and <scene name='pdbligand=BHO:BENZHYDROXAMIC ACID'>BHO</scene>
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|ACTIVITY= [http://en.wikipedia.org/wiki/Peroxidase Peroxidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.11.1.7 1.11.1.7]
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|GENE=
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}}
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'''BINDING MODE OF BENZHYDROXAMIC ACID TO ARTHROMYCES RAMOSUS PEROXIDASE'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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1HSR is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Eukaryota Eukaryota] with <scene name='pdbligand=CA:'>CA</scene>, <scene name='pdbligand=HEM:'>HEM</scene> and <scene name='pdbligand=BHO:'>BHO</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Peroxidase Peroxidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.11.1.7 1.11.1.7] Known structural/functional Sites: <scene name='pdbsite=CA1:Active+Site'>CA1</scene>, <scene name='pdbsite=CA2:Active+Site'>CA2</scene> and <scene name='pdbsite=GL1:Active+Site'>GL1</scene>. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HSR OCA].
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1HSR is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Eukaryota Eukaryota]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HSR OCA].
==Reference==
==Reference==
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Binding mode of benzhydroxamic acid to Arthromyces ramosus peroxidase shown by X-ray crystallographic analysis of the complex at 1.6 A resolution., Itakura H, Oda Y, Fukuyama K, FEBS Lett. 1997 Jul 21;412(1):107-10. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=9257700 9257700]
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Binding mode of benzhydroxamic acid to Arthromyces ramosus peroxidase shown by X-ray crystallographic analysis of the complex at 1.6 A resolution., Itakura H, Oda Y, Fukuyama K, FEBS Lett. 1997 Jul 21;412(1):107-10. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9257700 9257700]
[[Category: Eukaryota]]
[[Category: Eukaryota]]
[[Category: Peroxidase]]
[[Category: Peroxidase]]
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[[Category: peroxidase]]
[[Category: peroxidase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 13:04:28 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 11:41:07 2008''

Revision as of 09:41, 20 March 2008

Image:1hsr.gif


PDB ID 1hsr

Drag the structure with the mouse to rotate
, resolution 1.60Å
Sites: , and
Ligands: , and
Activity: Peroxidase, with EC number 1.11.1.7
Coordinates: save as pdb, mmCIF, xml



BINDING MODE OF BENZHYDROXAMIC ACID TO ARTHROMYCES RAMOSUS PEROXIDASE


Overview

The crystal structure of Arthromyces ramosus peroxidase (ARP) in complex with benzhydroxamic acid (BHA) as determined by X-ray analysis at 1.6 A shows unambiguously how BHA binds to ARP. BHA is located in the distal heme pocket. Its functional groups are held by three hydrogen bonds to His56N(epsilon), Arg52N(epsilon), and Pro(154)O, but are too far away to interact with the heme iron. The aromatic ring of BHA is positioned at the entrance of the channel to the heme pocket, approximately parallel to the heme group. Most water molecules at the active site of the native enzyme are replaced by BHA, leaving a ligand, probably a water molecule, at the sixth position of the heme. Results are compared with spectroscopic data.

About this Structure

1HSR is a Single protein structure of sequence from Eukaryota. Full crystallographic information is available from OCA.

Reference

Binding mode of benzhydroxamic acid to Arthromyces ramosus peroxidase shown by X-ray crystallographic analysis of the complex at 1.6 A resolution., Itakura H, Oda Y, Fukuyama K, FEBS Lett. 1997 Jul 21;412(1):107-10. PMID:9257700

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