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2b9b

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[[Image:2b9b.png|left|200px]]
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==Structure of the Parainfluenza Virus 5 F Protein in its Metastable, Pre-fusion Conformation==
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<StructureSection load='2b9b' size='340' side='right' caption='[[2b9b]], [[Resolution|resolution]] 2.85&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2b9b]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Parainfluenza_virus_5 Parainfluenza virus 5]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2B9B OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2B9B FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene><br>
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<tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">F ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=11207 Parainfluenza virus 5])</td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2b9b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2b9b OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2b9b RCSB], [http://www.ebi.ac.uk/pdbsum/2b9b PDBsum]</span></td></tr>
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<table>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/b9/2b9b_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Enveloped viruses have evolved complex glycoprotein machinery that drives the fusion of viral and cellular membranes, permitting entry of the viral genome into the cell. For the paramyxoviruses, the fusion (F) protein catalyses this membrane merger and entry step, and it has been postulated that the F protein undergoes complex refolding during this process. Here we report the crystal structure of the parainfluenza virus 5 F protein in its prefusion conformation, stabilized by the addition of a carboxy-terminal trimerization domain. The structure of the F protein shows that there are profound conformational differences between the pre- and postfusion states, involving transformations in secondary and tertiary structure. The positions and structural transitions of key parts of the fusion machinery, including the hydrophobic fusion peptide and two helical heptad repeat regions, clarify the mechanism of membrane fusion mediated by the F protein.
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{{STRUCTURE_2b9b| PDB=2b9b | SCENE= }}
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Structure of the parainfluenza virus 5 F protein in its metastable, prefusion conformation.,Yin HS, Wen X, Paterson RG, Lamb RA, Jardetzky TS Nature. 2006 Jan 5;439(7072):38-44. PMID:16397490<ref>PMID:16397490</ref>
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===Structure of the Parainfluenza Virus 5 F Protein in its Metastable, Pre-fusion Conformation===
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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{{ABSTRACT_PUBMED_16397490}}
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== References ==
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<references/>
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==About this Structure==
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__TOC__
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[[2b9b]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Parainfluenza_virus_5 Parainfluenza virus 5]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2B9B OCA].
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</StructureSection>
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==Reference==
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<ref group="xtra">PMID:016397490</ref><references group="xtra"/>
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[[Category: Parainfluenza virus 5]]
[[Category: Parainfluenza virus 5]]
[[Category: Jardetzky, T S.]]
[[Category: Jardetzky, T S.]]

Revision as of 02:11, 30 September 2014

Structure of the Parainfluenza Virus 5 F Protein in its Metastable, Pre-fusion Conformation

2b9b, resolution 2.85Å

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