1hup
From Proteopedia
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| - | [[Image:1hup.gif|left|200px]] | + | [[Image:1hup.gif|left|200px]] |
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| - | '''HUMAN MANNOSE BINDING PROTEIN CARBOHYDRATE RECOGNITION DOMAIN TRIMERIZES THROUGH A TRIPLE ALPHA-HELICAL COILED-COIL''' | + | {{Structure |
| + | |PDB= 1hup |SIZE=350|CAPTION= <scene name='initialview01'>1hup</scene>, resolution 2.5Å | ||
| + | |SITE= | ||
| + | |LIGAND= <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene> and <scene name='pdbligand=SO4:SULFATE ION'>SO4</scene> | ||
| + | |ACTIVITY= | ||
| + | |GENE= | ||
| + | }} | ||
| + | |||
| + | '''HUMAN MANNOSE BINDING PROTEIN CARBOHYDRATE RECOGNITION DOMAIN TRIMERIZES THROUGH A TRIPLE ALPHA-HELICAL COILED-COIL''' | ||
| + | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1HUP is a [ | + | 1HUP is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HUP OCA]. |
==Reference== | ==Reference== | ||
| - | Human mannose-binding protein carbohydrate recognition domain trimerizes through a triple alpha-helical coiled-coil., Sheriff S, Chang CY, Ezekowitz RA, Nat Struct Biol. 1994 Nov;1(11):789-94. PMID:[http:// | + | Human mannose-binding protein carbohydrate recognition domain trimerizes through a triple alpha-helical coiled-coil., Sheriff S, Chang CY, Ezekowitz RA, Nat Struct Biol. 1994 Nov;1(11):789-94. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/7634089 7634089] |
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
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[[Category: alpha-helical coiled-coil]] | [[Category: alpha-helical coiled-coil]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 11:41:48 2008'' |
Revision as of 09:41, 20 March 2008
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| Ligands: | and | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
HUMAN MANNOSE BINDING PROTEIN CARBOHYDRATE RECOGNITION DOMAIN TRIMERIZES THROUGH A TRIPLE ALPHA-HELICAL COILED-COIL
Overview
Human mannose-binding protein is a hexamer of trimers with each subunit consisting of an amino-terminal region rich in cysteine, 19 collagen repeats, a 'neck', and a carbohydrate recognition domain that requires calcium to bind ligand. A 148-residue peptide, consisting of the 'neck' and carbohydrate recognition domains forms trimers in solution and in crystals. The structure of this trimeric peptide has been determined in two different crystal forms. The 'neck' forms a triple alpha-helical coiled-coil. Each alpha-helix interacts with a neighbouring carbohydrate recognition domain. The spatial arrangement of the carbohydrate recognition domains suggest how MBP trimers form the basic recognition unit for branched oligosaccharides on microorganisms.
About this Structure
1HUP is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Human mannose-binding protein carbohydrate recognition domain trimerizes through a triple alpha-helical coiled-coil., Sheriff S, Chang CY, Ezekowitz RA, Nat Struct Biol. 1994 Nov;1(11):789-94. PMID:7634089
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