2a98

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{{STRUCTURE_2a98| PDB=2a98 | SCENE= }}
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==Crystal structure of the catalytic domain of human inositol 1,4,5-trisphosphate 3-kinase C==
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===Crystal structure of the catalytic domain of human inositol 1,4,5-trisphosphate 3-kinase C===
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<StructureSection load='2a98' size='340' side='right' caption='[[2a98]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
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== Structural highlights ==
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==Disease==
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<table><tr><td colspan='2'>[[2a98]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2A98 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2A98 FirstGlance]. <br>
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[[http://www.uniprot.org/uniprot/IP3KC_HUMAN IP3KC_HUMAN]] Defects in ITPKC are a cause of Kawasaki disease (KWD) [MIM:[http://omim.org/entry/611775 611775]]; also known as mucocutaneous lymph node syndrome or infantile polyarteritis. Kawasaki disease is an acute, self-limited vasculitis of infants and children characterized by prolonged fever unresponsive to antibiotics, polymorphous skin rash, erythema of the oral mucosa, lips, and tongue, erythema of the palms and soles, bilateral conjunctival injection, and cervical lymphadenopathy. Coronary artery aneurysms develop in 15 to 25% of those left untreated, making Kawasaki disease the leading cause of acquired heart disease among children in developed countries.<ref>PMID:18157129</ref>
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</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=I3P:D-MYO-INOSITOL-1,4,5-TRIPHOSPHATE'>I3P</scene><br>
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<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Inositol-trisphosphate_3-kinase Inositol-trisphosphate 3-kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.127 2.7.1.127] </span></td></tr>
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==Function==
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2a98 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2a98 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2a98 RCSB], [http://www.ebi.ac.uk/pdbsum/2a98 PDBsum]</span></td></tr>
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<table>
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== Disease ==
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[[http://www.uniprot.org/uniprot/IP3KC_HUMAN IP3KC_HUMAN]] Defects in ITPKC are a cause of Kawasaki disease (KWD) [MIM:[http://omim.org/entry/611775 611775]]; also known as mucocutaneous lymph node syndrome or infantile polyarteritis. Kawasaki disease is an acute, self-limited vasculitis of infants and children characterized by prolonged fever unresponsive to antibiotics, polymorphous skin rash, erythema of the oral mucosa, lips, and tongue, erythema of the palms and soles, bilateral conjunctival injection, and cervical lymphadenopathy. Coronary artery aneurysms develop in 15 to 25% of those left untreated, making Kawasaki disease the leading cause of acquired heart disease among children in developed countries.<ref>PMID:18157129</ref>
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== Function ==
[[http://www.uniprot.org/uniprot/IP3KC_HUMAN IP3KC_HUMAN]] Can phosphorylate inositol 2,4,5-triphosphate to inositol 2,4,5,6-tetraphosphate (By similarity).
[[http://www.uniprot.org/uniprot/IP3KC_HUMAN IP3KC_HUMAN]] Can phosphorylate inositol 2,4,5-triphosphate to inositol 2,4,5,6-tetraphosphate (By similarity).
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== Evolutionary Conservation ==
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==About this Structure==
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[[Image:Consurf_key_small.gif|200px|right]]
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[[2a98]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2A98 OCA].
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Check<jmol>
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<jmolCheckbox>
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==Reference==
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/a9/2a98_consurf.spt"</scriptWhenChecked>
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<references group="xtra"/><references/>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
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<div style="clear:both"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Inositol-trisphosphate 3-kinase]]
[[Category: Inositol-trisphosphate 3-kinase]]

Revision as of 02:19, 30 September 2014

Crystal structure of the catalytic domain of human inositol 1,4,5-trisphosphate 3-kinase C

2a98, resolution 2.60Å

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