1zv7

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[[Image:1zv7.png|left|200px]]
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==A structure-based mechanism of SARS virus membrane fusion==
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<StructureSection load='1zv7' size='340' side='right' caption='[[1zv7]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1zv7]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Sars_coronavirus_fra Sars coronavirus fra]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZV7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ZV7 FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene><br>
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<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1zv8|1zv8]], [[1zva|1zva]], [[1zvb|1zvb]]</td></tr>
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<tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">S ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=242743 SARS coronavirus FRA])</td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1zv7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zv7 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1zv7 RCSB], [http://www.ebi.ac.uk/pdbsum/1zv7 PDBsum]</span></td></tr>
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<table>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/zv/1zv7_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Entry of SARS coronavirus into its target cell requires large-scale structural transitions in the viral spike (S) glycoprotein in order to induce fusion of the virus and cell membranes. Here we describe the identification and crystal structures of four distinct alpha-helical domains derived from the highly conserved heptad-repeat (HR) regions of the S2 fusion subunit. The four domains are an antiparallel four-stranded coiled coil, a parallel trimeric coiled coil, a four-helix bundle, and a six-helix bundle that is likely the final fusogenic form of the protein. When considered together, the structural and thermodynamic features of the four domains suggest a possible mechanism whereby the HR regions, initially sequestered in the native S glycoprotein spike, are released and refold sequentially to promote membrane fusion. Our results provide a structural framework for understanding the control of membrane fusion and should guide efforts to intervene in the SARS coronavirus entry process.
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{{STRUCTURE_1zv7| PDB=1zv7 | SCENE= }}
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Structures and polymorphic interactions of two heptad-repeat regions of the SARS virus S2 protein.,Deng Y, Liu J, Zheng Q, Yong W, Lu M Structure. 2006 May;14(5):889-99. PMID:16698550<ref>PMID:16698550</ref>
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===A structure-based mechanism of SARS virus membrane fusion===
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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{{ABSTRACT_PUBMED_16698550}}
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== References ==
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<references/>
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==About this Structure==
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__TOC__
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[[1zv7]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Sars_coronavirus_fra Sars coronavirus fra]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZV7 OCA].
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</StructureSection>
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==Reference==
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<ref group="xtra">PMID:016698550</ref><references group="xtra"/>
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[[Category: Sars coronavirus fra]]
[[Category: Sars coronavirus fra]]
[[Category: Dai, J.]]
[[Category: Dai, J.]]

Revision as of 02:22, 30 September 2014

A structure-based mechanism of SARS virus membrane fusion

1zv7, resolution 1.70Å

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OCA

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