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2afv

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[[Image:2afv.png|left|200px]]
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==The Crystal Structure of Putative Precorrin Isomerase CbiC in Cobalamin Biosynthesis==
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<StructureSection load='2afv' size='340' side='right' caption='[[2afv]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2afv]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Leptospira_interrogans Leptospira interrogans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AFV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2AFV FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=P33:3,6,9,12,15,18-HEXAOXAICOSANE-1,20-DIOL'>P33</scene>, <scene name='pdbligand=P6G:HEXAETHYLENE+GLYCOL'>P6G</scene><br>
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<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2afr|2afr]]</td></tr>
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<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Precorrin-8X_methylmutase Precorrin-8X methylmutase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.4.1.2 5.4.1.2] </span></td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2afv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2afv OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2afv RCSB], [http://www.ebi.ac.uk/pdbsum/2afv PDBsum]</span></td></tr>
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<table>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/af/2afv_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The leptospira cbiC encodes the enzyme catalyzing the methyl rearrangement reaction of the cobalamin biosynthesis pathway. The protein has been cloned and overexpressed as a His-tagged recombinant protein in Escherichia coli. The crystal structures have been solved in two crystal forms (P4(2)2(1)2 and P3(1)21) diffracting to 3.0 and 2.3A resolution, respectively. The structures are similar to the precorrin-8x methyl mutase (CobH), an enzyme of the aerobic pathway to vitamin B12.
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{{STRUCTURE_2afv| PDB=2afv | SCENE= }}
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The crystal structure of putative precorrin isomerase CbiC in cobalamin biosynthesis.,Xue Y, Wei Z, Li X, Gong W J Struct Biol. 2006 Mar;153(3):307-11. Epub 2005 Dec 27. PMID:16427313<ref>PMID:16427313</ref>
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===The Crystal Structure of Putative Precorrin Isomerase CbiC in Cobalamin Biosynthesis===
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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{{ABSTRACT_PUBMED_16427313}}
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== References ==
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<references/>
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==About this Structure==
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__TOC__
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[[2afv]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Leptospira_interrogans Leptospira interrogans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AFV OCA].
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</StructureSection>
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==Reference==
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<ref group="xtra">PMID:016427313</ref><references group="xtra"/>
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[[Category: Leptospira interrogans]]
[[Category: Leptospira interrogans]]
[[Category: Precorrin-8X methylmutase]]
[[Category: Precorrin-8X methylmutase]]

Revision as of 02:28, 30 September 2014

The Crystal Structure of Putative Precorrin Isomerase CbiC in Cobalamin Biosynthesis

2afv, resolution 3.00Å

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