1hxn
From Proteopedia
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| - | [[Image:1hxn.gif|left|200px]] | + | [[Image:1hxn.gif|left|200px]] |
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| - | '''1.8 ANGSTROMS CRYSTAL STRUCTURE OF THE C-TERMINAL DOMAIN OF RABBIT SERUM HEMOPEXIN''' | + | {{Structure |
| + | |PDB= 1hxn |SIZE=350|CAPTION= <scene name='initialview01'>1hxn</scene>, resolution 1.8Å | ||
| + | |SITE= | ||
| + | |LIGAND= <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene> and <scene name='pdbligand=CL:CHLORIDE ION'>CL</scene> | ||
| + | |ACTIVITY= | ||
| + | |GENE= | ||
| + | }} | ||
| + | |||
| + | '''1.8 ANGSTROMS CRYSTAL STRUCTURE OF THE C-TERMINAL DOMAIN OF RABBIT SERUM HEMOPEXIN''' | ||
| + | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1HXN is a [ | + | 1HXN is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HXN OCA]. |
==Reference== | ==Reference== | ||
| - | 1.8 A crystal structure of the C-terminal domain of rabbit serum haemopexin., Faber HR, Groom CR, Baker HM, Morgan WT, Smith A, Baker EN, Structure. 1995 Jun 15;3(6):551-9. PMID:[http:// | + | 1.8 A crystal structure of the C-terminal domain of rabbit serum haemopexin., Faber HR, Groom CR, Baker HM, Morgan WT, Smith A, Baker EN, Structure. 1995 Jun 15;3(6):551-9. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/8590016 8590016] |
[[Category: Oryctolagus cuniculus]] | [[Category: Oryctolagus cuniculus]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
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[[Category: heme]] | [[Category: heme]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 11:42:50 2008'' |
Revision as of 09:42, 20 March 2008
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| , resolution 1.8Å | |||||||
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| Ligands: | , and | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
1.8 ANGSTROMS CRYSTAL STRUCTURE OF THE C-TERMINAL DOMAIN OF RABBIT SERUM HEMOPEXIN
Overview
BACKGROUND: Haemopexin is a serum glycoprotein that binds haem reversibly and delivers it to the liver where it is taken up by receptor-mediated endocytosis. Haemopexin has two homologous domains, each having a characteristic fourfold internal sequence repeat. Haemopexin-type domains are also found in other proteins, including the serum adhesion protein vitronectin and various collagenases, in which they mediate protein-protein interactions. RESULTS: We have determined the crystal structure of the C-terminal domain of haemopexin at 1.8 A resolution. The domain is folded into four beta-leaflet modules, arranged in succession around a central pseudo-fourfold axis. A funnel-shaped tunnel through the centre of this disc-shaped domain serves as an ion-binding site. CONCLUSIONS: A model for haem binding by haemopexin is proposed, utilizing an anion-binding site at the wider end of the central tunnel, together with an associated cleft. This parallels the active-site location in other beta-propeller structures. The capacity to bind both cations and anions, together with the disc shape of the domain, suggests that such domains may be used widely for macromolecular recognition.
About this Structure
1HXN is a Single protein structure of sequence from Oryctolagus cuniculus. Full crystallographic information is available from OCA.
Reference
1.8 A crystal structure of the C-terminal domain of rabbit serum haemopexin., Faber HR, Groom CR, Baker HM, Morgan WT, Smith A, Baker EN, Structure. 1995 Jun 15;3(6):551-9. PMID:8590016
Page seeded by OCA on Thu Mar 20 11:42:50 2008
Categories: Oryctolagus cuniculus | Single protein | Baker, E N. | Faber, H R. | CL | NA | PO4 | Heme
