1hyi

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[[Image:1hyi.jpg|left|200px]]<br /><applet load="1hyi" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:1hyi.jpg|left|200px]]
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caption="1hyi" />
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'''SOLUTION STRUCTURE OF THE EEA1 FYVE DOMAIN COMPLEXED WITH INOSITOL 1,3-BISPHOSPHATE'''<br />
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{{Structure
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|PDB= 1hyi |SIZE=350|CAPTION= <scene name='initialview01'>1hyi</scene>
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|SITE=
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|LIGAND= <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene> and <scene name='pdbligand=ITP:PHOSPHORIC ACID MONO-(2,3,4,6-TETRAHYDROXY-5-PHOSPHONOOXY-CYCLOHEXYL) ESTER'>ITP</scene>
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|ACTIVITY=
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|GENE=
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}}
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'''SOLUTION STRUCTURE OF THE EEA1 FYVE DOMAIN COMPLEXED WITH INOSITOL 1,3-BISPHOSPHATE'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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1HYI is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=ZN:'>ZN</scene> and <scene name='pdbligand=ITP:'>ITP</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HYI OCA].
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1HYI is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HYI OCA].
==Reference==
==Reference==
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Structural mechanism of endosome docking by the FYVE domain., Kutateladze T, Overduin M, Science. 2001 Mar 2;291(5509):1793-6. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=11230696 11230696]
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Structural mechanism of endosome docking by the FYVE domain., Kutateladze T, Overduin M, Science. 2001 Mar 2;291(5509):1793-6. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11230696 11230696]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: zinc cluster]]
[[Category: zinc cluster]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 13:06:05 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 11:43:10 2008''

Revision as of 09:43, 20 March 2008

Image:1hyi.jpg


PDB ID 1hyi

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Ligands: and
Coordinates: save as pdb, mmCIF, xml



SOLUTION STRUCTURE OF THE EEA1 FYVE DOMAIN COMPLEXED WITH INOSITOL 1,3-BISPHOSPHATE


Contents

Overview

The recruitment of trafficking and signaling proteins to membranes containing phosphatidylinositol 3-phosphate [PtdIns(3)P] is mediated by FYVE domains. Here, the solution structure of the FYVE domain of the early endosome antigen 1 protein (EEA1) in the free state was compared with the structures of the domain complexed with PtdIns(3)P and mixed micelles. The multistep binding mechanism involved nonspecific insertion of a hydrophobic loop into the lipid bilayer, positioning and activating the binding pocket. Ligation of PtdIns(3)P then induced a global structural change, drawing the protein termini over the bound phosphoinositide by extension of a hinge. Specific recognition of the 3-phosphate was determined indirectly and directly by two clusters of conserved arginines.

Disease

Known disease associated with this structure: Spastic paraplegia 33 OMIM:[610243]

About this Structure

1HYI is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structural mechanism of endosome docking by the FYVE domain., Kutateladze T, Overduin M, Science. 2001 Mar 2;291(5509):1793-6. PMID:11230696

Page seeded by OCA on Thu Mar 20 11:43:10 2008

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