2jsy

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[[Image:2jsy.png|left|200px]]
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==Solution structure of Tpx in the oxidized state==
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<StructureSection load='2jsy' size='340' side='right' caption='[[2jsy]], [[NMR_Ensembles_of_Models | 21 NMR models]]' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2jsy]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JSY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2JSY FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">tpx, ytgI ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1423 Bacillus subtilis])</td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jsy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jsy OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2jsy RCSB], [http://www.ebi.ac.uk/pdbsum/2jsy PDBsum]</span></td></tr>
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<table>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/js/2jsy_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Bacterial thiol peroxidase (Tpx) is the periplasmic antioxidant enzyme widely distributed in most bacterial species, which catalyzes the reduction of lipid hydroperoxide in vivo. Tpx belongs to the atypical 2-Cys peroxiredoxin (Prx) family and utilizes two active cysteine residues during the redox reaction. Although several crystal structures of Tpx are available, no pair of the redox structures reported thus far. Therefore, the conformational changes coupled to the catalytic reaction remain unclear. Herein, we report the solution structures of Bacillus subtilis Tpx in both the reduced and oxidized forms, the first pair of Tpx structures. The overall structures of both forms are very similar, however, significant differences at the active regions around the C(P) and C(R) residues were observed. In particular, a helix-to-coil transition was observed at the C(R) region between the two forms. Our study reveals a dynamic picture of the conformational switch coupled to the redox reaction, thus provides further insights in understanding the catalytic mechanism of bacterial Tpx.
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{{STRUCTURE_2jsy| PDB=2jsy | SCENE= }}
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Reversible conformational switch revealed by the redox structures of Bacillus subtilis thiol peroxidase.,Lu J, Yang F, Li Y, Zhang X, Xia B, Jin C Biochem Biophys Res Commun. 2008 Aug 29;373(3):414-8. Epub 2008 Jun 25. PMID:18588855<ref>PMID:18588855</ref>
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===Solution structure of Tpx in the oxidized state===
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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{{ABSTRACT_PUBMED_18588855}}
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== References ==
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<references/>
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==About this Structure==
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__TOC__
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[[2jsy]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JSY OCA].
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</StructureSection>
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==Reference==
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<ref group="xtra">PMID:018588855</ref><references group="xtra"/>
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[[Category: Bacillus subtilis]]
[[Category: Bacillus subtilis]]
[[Category: Jin, C.]]
[[Category: Jin, C.]]

Revision as of 08:25, 30 September 2014

Solution structure of Tpx in the oxidized state

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