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2k9h

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[[Image:2k9h.png|left|200px]]
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==The hantavirus glycoprotein G1 tail contains a dual CCHC-type classical zinc fingers==
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<StructureSection load='2k9h' size='340' side='right' caption='[[2k9h]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2k9h]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Andes_virus Andes virus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2K9H OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2K9H FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene><br>
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<tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">AF028026 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=46607 Andes virus])</td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2k9h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2k9h OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2k9h RCSB], [http://www.ebi.ac.uk/pdbsum/2k9h PDBsum]</span></td></tr>
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<table>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/k9/2k9h_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Hantaviruses are distributed worldwide and can cause a hemorrhagic fever or a cardiopulmonary syndrome in humans. Mature virions consist of RNA genome, nucleocapsid protein, RNA polymerase, and two transmembrane glycoproteins, G1 and G2. The ectodomain of G1 is surface-exposed; however, it has a 142-residue C-terminal cytoplasmic tail that plays important roles in viral assembly and host-pathogen interaction. Here we show by NMR, circular dichroism spectroscopy, and mutagenesis that a highly conserved cysteine/histidine-rich region in the G1 tail of hantaviruses forms two CCHC-type classical zinc fingers. Unlike classical zinc fingers, however, the two G1 zinc fingers are intimately joined together, forming a compact domain with a unique fold. We discuss the implication of the hantaviral G1 zinc fingers in viral assembly and host-pathogen interaction.
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{{STRUCTURE_2k9h| PDB=2k9h | SCENE= }}
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The Hantavirus Glycoprotein G1 Tail Contains Dual CCHC-type Classical Zinc Fingers.,Estrada DF, Boudreaux DM, Zhong D, St Jeor SC, De Guzman RN J Biol Chem. 2009 Mar 27;284(13):8654-60. Epub 2009 Jan 29. PMID:19179334<ref>PMID:19179334</ref>
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===The hantavirus glycoprotein G1 tail contains a dual CCHC-type classical zinc fingers===
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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{{ABSTRACT_PUBMED_19179334}}
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== References ==
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<references/>
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==About this Structure==
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__TOC__
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[[2k9h]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Andes_virus Andes virus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2K9H OCA].
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</StructureSection>
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==Reference==
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<ref group="xtra">PMID:019179334</ref><references group="xtra"/>
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[[Category: Andes virus]]
[[Category: Andes virus]]
[[Category: Boudreaux, D M.]]
[[Category: Boudreaux, D M.]]

Revision as of 09:23, 30 September 2014

The hantavirus glycoprotein G1 tail contains a dual CCHC-type classical zinc fingers

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