2jqm
From Proteopedia
(Difference between revisions)
m (Protected "2jqm" [edit=sysop:move=sysop]) |
|||
| Line 1: | Line 1: | ||
| - | [[ | + | ==Yellow Fever Envelope Protein Domain III NMR Structure (S288-K398)== |
| + | <StructureSection load='2jqm' size='340' side='right' caption='[[2jqm]], [[NMR_Ensembles_of_Models | 19 NMR models]]' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[2jqm]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Yellow_fever_virus Yellow fever virus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JQM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2JQM FirstGlance]. <br> | ||
| + | </td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jqm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jqm OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2jqm RCSB], [http://www.ebi.ac.uk/pdbsum/2jqm PDBsum]</span></td></tr> | ||
| + | <table> | ||
| + | == Evolutionary Conservation == | ||
| + | [[Image:Consurf_key_small.gif|200px|right]] | ||
| + | Check<jmol> | ||
| + | <jmolCheckbox> | ||
| + | <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jq/2jqm_consurf.spt"</scriptWhenChecked> | ||
| + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
| + | <text>to colour the structure by Evolutionary Conservation</text> | ||
| + | </jmolCheckbox> | ||
| + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf]. | ||
| + | <div style="clear:both"></div> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | The structure of recombinant domain III of the envelope protein (rED3) of yellow fever virus (YFV), containing the major neutralization site, was determined using NMR spectroscopy. The amino acid sequence and structure of the YFV-rED3 shows differences from ED3s of other mosquito-borne flaviviruses; in particular, the partially surface-exposed BC loop where methionine-304 and valine-324 were identified as being critical for the structure of the loop. Variations in the structure and surface chemistry of ED3 between flaviviruses affect neutralization sites and may affect host cell receptor interactions and play a role in the observed variations in viral pathogenesis and tissue tropism. | ||
| - | + | Structure of yellow fever virus envelope protein domain III.,Volk DE, May FJ, Gandham SH, Anderson A, Von Lindern JJ, Beasley DW, Barrett AD, Gorenstein DG Virology. 2009 Nov 10;394(1):12-8. Epub 2009 Oct 8. PMID:19818466<ref>PMID:19818466</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | + | </div> | |
| - | + | == References == | |
| - | + | <references/> | |
| - | + | __TOC__ | |
| - | + | </StructureSection> | |
| - | + | ||
| - | == | + | |
| - | < | + | |
[[Category: Yellow fever virus]] | [[Category: Yellow fever virus]] | ||
[[Category: Anderson, A.]] | [[Category: Anderson, A.]] | ||
Revision as of 09:35, 30 September 2014
Yellow Fever Envelope Protein Domain III NMR Structure (S288-K398)
| |||||||||||
