1i69

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[[Image:1i69.jpg|left|200px]]<br /><applet load="1i69" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:1i69.jpg|left|200px]]
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caption="1i69, resolution 2.7&Aring;" />
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'''CRYSTAL STRUCTURE OF THE REDUCED FORM OF OXYR'''<br />
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{{Structure
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|PDB= 1i69 |SIZE=350|CAPTION= <scene name='initialview01'>1i69</scene>, resolution 2.7&Aring;
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|SITE=
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|LIGAND= <scene name='pdbligand=BEZ:BENZOIC ACID'>BEZ</scene>
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|ACTIVITY=
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|GENE=
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}}
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'''CRYSTAL STRUCTURE OF THE REDUCED FORM OF OXYR'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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1I69 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] with <scene name='pdbligand=BEZ:'>BEZ</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1I69 OCA].
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1I69 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1I69 OCA].
==Reference==
==Reference==
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Structural basis of the redox switch in the OxyR transcription factor., Choi H, Kim S, Mukhopadhyay P, Cho S, Woo J, Storz G, Ryu S, Cell. 2001 Apr 6;105(1):103-13. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=11301006 11301006]
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Structural basis of the redox switch in the OxyR transcription factor., Choi H, Kim S, Mukhopadhyay P, Cho S, Woo J, Storz G, Ryu S, Cell. 2001 Apr 6;105(1):103-13. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11301006 11301006]
[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: reduced form]]
[[Category: reduced form]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 13:08:21 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 11:46:00 2008''

Revision as of 09:46, 20 March 2008

Image:1i69.jpg


PDB ID 1i69

Drag the structure with the mouse to rotate
, resolution 2.7Å
Ligands:
Coordinates: save as pdb, mmCIF, xml



CRYSTAL STRUCTURE OF THE REDUCED FORM OF OXYR


Overview

The Escherichia coli OxyR transcription factor senses H2O2 and is activated through the formation of an intramolecular disulfide bond. Here we present the crystal structures of the regulatory domain of OxyR in its reduced and oxidized forms, determined at 2.7 A and 2.3 A resolutions, respectively. In the reduced form, the two redox-active cysteines are separated by approximately 17 A. Disulfide bond formation in the oxidized form results in a significant structural change in the regulatory domain. The structural remodeling, which leads to different oligomeric associations, accounts for the redox-dependent switch in OxyR and provides a novel example of protein regulation by "fold editing" through a reversible disulfide bond formation within a folded domain.

About this Structure

1I69 is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

Structural basis of the redox switch in the OxyR transcription factor., Choi H, Kim S, Mukhopadhyay P, Cho S, Woo J, Storz G, Ryu S, Cell. 2001 Apr 6;105(1):103-13. PMID:11301006

Page seeded by OCA on Thu Mar 20 11:46:00 2008

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