1i9k

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[[Image:1i9k.gif|left|200px]]<br /><applet load="1i9k" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:1i9k.gif|left|200px]]
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caption="1i9k" />
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'''THE RNA I-MOTIF'''<br />
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{{Structure
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|PDB= 1i9k |SIZE=350|CAPTION= <scene name='initialview01'>1i9k</scene>
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|SITE=
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|LIGAND=
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|ACTIVITY=
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|GENE=
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}}
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'''THE RNA I-MOTIF'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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1I9K is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1I9K OCA].
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1I9K is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1I9K OCA].
==Reference==
==Reference==
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The RNA i-motif., Snoussi K, Nonin-Lecomte S, Leroy JL, J Mol Biol. 2001 May 25;309(1):139-53. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=11491284 11491284]
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The RNA i-motif., Snoussi K, Nonin-Lecomte S, Leroy JL, J Mol Biol. 2001 May 25;309(1):139-53. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11491284 11491284]
[[Category: Protein complex]]
[[Category: Protein complex]]
[[Category: Lerou, J L.]]
[[Category: Lerou, J L.]]
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[[Category: rna]]
[[Category: rna]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 13:09:26 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 11:47:20 2008''

Revision as of 09:47, 20 March 2008

Image:1i9k.gif


PDB ID 1i9k

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Coordinates: save as pdb, mmCIF, xml



THE RNA I-MOTIF


Overview

Oligodeoxynucleotides with stretches of cytidine residues associate into a four-stranded structure, the i-motif, in which two head-to-tail, intercalated, parallel-stranded duplexes are held together by hemiprotonated C.C+ pairs. We have investigated the possibility of forming an i-motif structure with C-rich ribonucleic acids. The four C-rich RNAs studied, r(UC5), r(C5), r(C5U) and r(UC3), associate into multiple intercalated structures at acidic pH. r(UC5) forms two i-motif structures that differ by their intercalation topologies. We report on a structural study of the main form and we analyze the small conformational differences found by comparison with the DNA i-motif. The stacking topology of the main structure avoids one of the six 2'-OH/2'-OH repulsive contacts expected in a fully intercalated structure. The C3'-endo pucker of the RNA sugars and the orientation of the intercalated C.C+ pairs result in a modest widening of the narrow grooves at the steps where the hydroxyl groups are in close contact. The free energy of the RNA i-motif, on average -4 kJ mol(-1) per C.C+ pair, is half of the value found in DNA i-motif structures.

About this Structure

1I9K is a Protein complex structure of sequences from [1]. Full crystallographic information is available from OCA.

Reference

The RNA i-motif., Snoussi K, Nonin-Lecomte S, Leroy JL, J Mol Biol. 2001 May 25;309(1):139-53. PMID:11491284

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