1i9w

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[[Image:1i9w.gif|left|200px]]<br /><applet load="1i9w" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:1i9w.gif|left|200px]]
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caption="1i9w, resolution 3.0&Aring;" />
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'''CRYSTAL STRUCTURE OF THE FUSION GLYCOPROTEIN E1 FROM SEMLIKI FOREST VIRUS'''<br />
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{{Structure
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|PDB= 1i9w |SIZE=350|CAPTION= <scene name='initialview01'>1i9w</scene>, resolution 3.0&Aring;
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|SITE=
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|LIGAND=
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|ACTIVITY=
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|GENE=
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}}
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'''CRYSTAL STRUCTURE OF THE FUSION GLYCOPROTEIN E1 FROM SEMLIKI FOREST VIRUS'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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1I9W is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Semliki_forest_virus Semliki forest virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1I9W OCA].
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1I9W is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Semliki_forest_virus Semliki forest virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1I9W OCA].
==Reference==
==Reference==
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The Fusion glycoprotein shell of Semliki Forest virus: an icosahedral assembly primed for fusogenic activation at endosomal pH., Lescar J, Roussel A, Wien MW, Navaza J, Fuller SD, Wengler G, Wengler G, Rey FA, Cell. 2001 Apr 6;105(1):137-48. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=11301009 11301009]
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The Fusion glycoprotein shell of Semliki Forest virus: an icosahedral assembly primed for fusogenic activation at endosomal pH., Lescar J, Roussel A, Wien MW, Navaza J, Fuller SD, Wengler G, Wengler G, Rey FA, Cell. 2001 Apr 6;105(1):137-48. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11301009 11301009]
[[Category: Semliki forest virus]]
[[Category: Semliki forest virus]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: virus]]
[[Category: virus]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 13:09:32 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 11:47:29 2008''

Revision as of 09:47, 20 March 2008

Image:1i9w.gif


PDB ID 1i9w

Drag the structure with the mouse to rotate
, resolution 3.0Å
Coordinates: save as pdb, mmCIF, xml



CRYSTAL STRUCTURE OF THE FUSION GLYCOPROTEIN E1 FROM SEMLIKI FOREST VIRUS


Overview

Semliki Forest virus (SFV) has been extensively studied as a model for analyzing entry of enveloped viruses into target cells. Here we describe the trace of the polypeptide chain of the SFV fusion glycoprotein, E1, derived from an electron density map at 3.5 A resolution and describe its interactions at the surface of the virus. E1 is unexpectedly similar to the flavivirus envelope protein, with three structural domains disposed in the same primary sequence arrangement. These results introduce a new class of membrane fusion proteins which display lateral interactions to induce the necessary curvature and direct budding of closed particles. The resulting surface protein lattice is primed to cause membrane fusion when exposed to the acidic environment of the endosome.

About this Structure

1I9W is a Single protein structure of sequence from Semliki forest virus. Full crystallographic information is available from OCA.

Reference

The Fusion glycoprotein shell of Semliki Forest virus: an icosahedral assembly primed for fusogenic activation at endosomal pH., Lescar J, Roussel A, Wien MW, Navaza J, Fuller SD, Wengler G, Wengler G, Rey FA, Cell. 2001 Apr 6;105(1):137-48. PMID:11301009

Page seeded by OCA on Thu Mar 20 11:47:29 2008

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