1iap

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[[Image:1iap.jpg|left|200px]]<br /><applet load="1iap" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:1iap.jpg|left|200px]]
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caption="1iap, resolution 1.90&Aring;" />
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'''CRYSTAL STRUCTURE OF P115RHOGEF RGRGS DOMAIN'''<br />
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{{Structure
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|PDB= 1iap |SIZE=350|CAPTION= <scene name='initialview01'>1iap</scene>, resolution 1.90&Aring;
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|SITE=
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|LIGAND=
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|ACTIVITY=
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|GENE=
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}}
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'''CRYSTAL STRUCTURE OF P115RHOGEF RGRGS DOMAIN'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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1IAP is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IAP OCA].
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1IAP is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IAP OCA].
==Reference==
==Reference==
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Structure of the rgRGS domain of p115RhoGEF., Chen Z, Wells CD, Sternweis PC, Sprang SR, Nat Struct Biol. 2001 Sep;8(9):805-9. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=11524686 11524686]
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Structure of the rgRGS domain of p115RhoGEF., Chen Z, Wells CD, Sternweis PC, Sprang SR, Nat Struct Biol. 2001 Sep;8(9):805-9. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11524686 11524686]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: Sprang, S R.]]
[[Category: Sprang, S R.]]
[[Category: p115]]
[[Category: p115]]
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[[Category: rgrgs]]
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[[Category: rgrg]]
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[[Category: rgs]]
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[[Category: rg]]
[[Category: rhogef]]
[[Category: rhogef]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 13:09:47 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 11:47:52 2008''

Revision as of 09:47, 20 March 2008

Image:1iap.jpg


PDB ID 1iap

Drag the structure with the mouse to rotate
, resolution 1.90Å
Coordinates: save as pdb, mmCIF, xml



CRYSTAL STRUCTURE OF P115RHOGEF RGRGS DOMAIN


Contents

Overview

p115RhoGEF, a guanine nucleotide exchange factor for Rho GTPase, is also a GTPase activating protein (GAP) for G(12) and G(13) heterotrimeric G alpha subunits. Near its N-terminus, p115RhoGEF contains a domain (rgRGS) with remote sequence identity to RGS (regulators of G protein signaling) domains. The rgRGS domain is necessary but not sufficient for the GAP activity of p115RhoGEF. The 1.9 A resolution crystal structure of the rgRGS domain shows structural similarity to RGS domains but possesses a C-terminal extension that folds into a layer of helices that pack against the hydrophobic core of the domain. Mutagenesis experiments show that rgRGS may form interactions with G alpha(13) that are analogous to those in complexes of RGS proteins with their G alpha substrates.

Disease

Known disease associated with this structure: Slowed nerve conduction velocity, AD OMIM:[608136]

About this Structure

1IAP is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structure of the rgRGS domain of p115RhoGEF., Chen Z, Wells CD, Sternweis PC, Sprang SR, Nat Struct Biol. 2001 Sep;8(9):805-9. PMID:11524686

Page seeded by OCA on Thu Mar 20 11:47:52 2008

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