1ibr

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[[Image:1ibr.gif|left|200px]]<br /><applet load="1ibr" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:1ibr.gif|left|200px]]
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caption="1ibr, resolution 2.30&Aring;" />
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'''COMPLEX OF RAN WITH IMPORTIN BETA'''<br />
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{{Structure
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|PDB= 1ibr |SIZE=350|CAPTION= <scene name='initialview01'>1ibr</scene>, resolution 2.30&Aring;
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|SITE=
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|LIGAND= <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene> and <scene name='pdbligand=GNP:PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER'>GNP</scene>
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|ACTIVITY=
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|GENE=
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}}
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'''COMPLEX OF RAN WITH IMPORTIN BETA'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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1IBR is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=MG:'>MG</scene> and <scene name='pdbligand=GNP:'>GNP</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IBR OCA].
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1IBR is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IBR OCA].
==Reference==
==Reference==
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Structural view of the Ran-Importin beta interaction at 2.3 A resolution., Vetter IR, Arndt A, Kutay U, Gorlich D, Wittinghofer A, Cell. 1999 May 28;97(5):635-46. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=10367892 10367892]
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Structural view of the Ran-Importin beta interaction at 2.3 A resolution., Vetter IR, Arndt A, Kutay U, Gorlich D, Wittinghofer A, Cell. 1999 May 28;97(5):635-46. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10367892 10367892]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Protein complex]]
[[Category: Protein complex]]
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[[Category: small gtpase; nuclear transport receptor]]
[[Category: small gtpase; nuclear transport receptor]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 13:10:09 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 11:48:11 2008''

Revision as of 09:48, 20 March 2008

Image:1ibr.gif


PDB ID 1ibr

Drag the structure with the mouse to rotate
, resolution 2.30Å
Ligands: and
Coordinates: save as pdb, mmCIF, xml



COMPLEX OF RAN WITH IMPORTIN BETA


Contents

Overview

Transport receptors of the Importin beta family shuttle between the nucleus and cytoplasm and mediate transport of macromolecules through nuclear pore complexes. They interact specifically with the GTP-binding protein Ran, which in turn regulates their interaction with cargo. Here, we report the three-dimensional structure of a complex between Ran bound to the nonhydrolyzable GTP analog GppNHp and a 462-residue fragment from Importin beta. The structure of Importin beta shows 10 tandem repeats resembling HEAT and Armadillo motifs. They form an irregular crescent, the concave site of which forms the interface with Ran-triphosphate. The importin-binding site of Ran does not overlap with that of the Ran-binding domain of RanBP2.

Disease

Known diseases associated with this structure: Osteolysis, familial expansile OMIM:[603499], Paget disease of bone OMIM:[603499]

About this Structure

1IBR is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structural view of the Ran-Importin beta interaction at 2.3 A resolution., Vetter IR, Arndt A, Kutay U, Gorlich D, Wittinghofer A, Cell. 1999 May 28;97(5):635-46. PMID:10367892

Page seeded by OCA on Thu Mar 20 11:48:11 2008

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