2ofm

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[[Image:2ofm.png|left|200px]]
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==1.11 A Crystal Structure of Apo Nitrophorin 4 From Rhodnius Prolixus==
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<StructureSection load='2ofm' size='340' side='right' caption='[[2ofm]], [[Resolution|resolution]] 1.11&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2ofm]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Rhodnius_prolixus Rhodnius prolixus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OFM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2OFM FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene><br>
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<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1x8o|1x8o]]</td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ofm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ofm OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2ofm RCSB], [http://www.ebi.ac.uk/pdbsum/2ofm PDBsum]</span></td></tr>
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<table>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/of/2ofm_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The nitrophorins from Rhodnius prolixus, the kissing bug, are heme-containing proteins used for the transport of nitric oxide to aide the insect in obtaining a blood meal. The Rhodnius nitrophorins display an eight-stranded antiparallel beta-barrel motif, typical of lipocalins, with a histidine-linked heme in the open end of the barrel. Heme is stabilized in the ferric state and highly distorted, displaying a ruffled conformation that may be of importance in the setting of the reduction potential. To help in understanding the means by which the protein matrix, an inherently soft material, is able to distort the heme from its low-energy planar conformation, we have determined the crystal structure of apo-nitrophorin 4-1.1 A resolution. Removal of the heme from nitrophorin 4 has very little effect on its structure: The heme binding cavity remains open and the loops near the cavity entrance respond to lower pH in the same manner as the intact protein. We conclude that the general stability of the lipocalin fold and apparent rigidity of the beta-barrel provide the means for distorting the heme cofactor.
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{{STRUCTURE_2ofm| PDB=2ofm | SCENE= }}
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Apo-nitrophorin 4 at atomic resolution.,Amoia AM, Montfort WR Protein Sci. 2007 Sep;16(9):2076-81. Epub 2007 Jul 27. PMID:17660249<ref>PMID:17660249</ref>
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===1.11 A Crystal Structure of Apo Nitrophorin 4 From Rhodnius Prolixus===
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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{{ABSTRACT_PUBMED_17660249}}
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== References ==
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<references/>
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==About this Structure==
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__TOC__
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[[2ofm]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Rhodnius_prolixus Rhodnius prolixus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OFM OCA].
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</StructureSection>
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==Reference==
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<ref group="xtra">PMID:017660249</ref><references group="xtra"/>
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[[Category: Rhodnius prolixus]]
[[Category: Rhodnius prolixus]]
[[Category: Amoia, A M.]]
[[Category: Amoia, A M.]]

Revision as of 19:03, 30 September 2014

1.11 A Crystal Structure of Apo Nitrophorin 4 From Rhodnius Prolixus

2ofm, resolution 1.11Å

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