1ici

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[[Image:1ici.gif|left|200px]]<br /><applet load="1ici" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:1ici.gif|left|200px]]
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caption="1ici, resolution 2.1&Aring;" />
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'''CRYSTAL STRUCTURE OF A SIR2 HOMOLOG-NAD COMPLEX'''<br />
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{{Structure
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|PDB= 1ici |SIZE=350|CAPTION= <scene name='initialview01'>1ici</scene>, resolution 2.1&Aring;
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|SITE=
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|LIGAND= <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene> and <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene>
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|ACTIVITY=
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|GENE= AF1676 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=2234 Archaeoglobus fulgidus])
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}}
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'''CRYSTAL STRUCTURE OF A SIR2 HOMOLOG-NAD COMPLEX'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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1ICI is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Archaeoglobus_fulgidus Archaeoglobus fulgidus] with <scene name='pdbligand=ZN:'>ZN</scene> and <scene name='pdbligand=NAD:'>NAD</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ICI OCA].
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1ICI is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Archaeoglobus_fulgidus Archaeoglobus fulgidus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ICI OCA].
==Reference==
==Reference==
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Crystal structure of a SIR2 homolog-NAD complex., Min J, Landry J, Sternglanz R, Xu RM, Cell. 2001 Apr 20;105(2):269-79. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=11336676 11336676]
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Crystal structure of a SIR2 homolog-NAD complex., Min J, Landry J, Sternglanz R, Xu RM, Cell. 2001 Apr 20;105(2):269-79. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11336676 11336676]
[[Category: Archaeoglobus fulgidus]]
[[Category: Archaeoglobus fulgidus]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: zinc ribbon]]
[[Category: zinc ribbon]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 13:10:21 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 11:48:34 2008''

Revision as of 09:48, 20 March 2008

Image:1ici.gif


PDB ID 1ici

Drag the structure with the mouse to rotate
, resolution 2.1Å
Ligands: and
Gene: AF1676 (Archaeoglobus fulgidus)
Coordinates: save as pdb, mmCIF, xml



CRYSTAL STRUCTURE OF A SIR2 HOMOLOG-NAD COMPLEX


Overview

The SIR2 protein family comprises a novel class of nicotinamide-adenine dinucleotide (NAD)-dependent protein deacetylases that function in transcriptional silencing, DNA repair, and life-span extension in Saccharomyces cerevisiae. Two crystal structures of a SIR2 homolog from Archaeoglobus fulgidus complexed with NAD have been determined at 2.1 A and 2.4 A resolutions. The structures reveal that the protein consists of a large domain having a Rossmann fold and a small domain containing a three-stranded zinc ribbon motif. NAD is bound in a pocket between the two domains. A distinct mode of NAD binding and an unusual configuration of the zinc ribbon motif are observed. The structures also provide important insights into the catalytic mechanism of NAD-dependent protein deacetylation by this family of enzymes.

About this Structure

1ICI is a Single protein structure of sequence from Archaeoglobus fulgidus. Full crystallographic information is available from OCA.

Reference

Crystal structure of a SIR2 homolog-NAD complex., Min J, Landry J, Sternglanz R, Xu RM, Cell. 2001 Apr 20;105(2):269-79. PMID:11336676

Page seeded by OCA on Thu Mar 20 11:48:34 2008

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