1ido
From Proteopedia
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| - | [[Image:1ido.gif|left|200px]] | + | [[Image:1ido.gif|left|200px]] |
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| - | '''I-DOMAIN FROM INTEGRIN CR3, MG2+ BOUND''' | + | {{Structure |
| + | |PDB= 1ido |SIZE=350|CAPTION= <scene name='initialview01'>1ido</scene>, resolution 1.7Å | ||
| + | |SITE= <scene name='pdbsite=MG:Metal+Binding+Site.+This+Site+Also+Includes+GLU+314+From+...'>MG</scene> | ||
| + | |LIGAND= <scene name='pdbligand=MG:MAGNESIUM ION'>MG</scene> | ||
| + | |ACTIVITY= | ||
| + | |GENE= | ||
| + | }} | ||
| + | |||
| + | '''I-DOMAIN FROM INTEGRIN CR3, MG2+ BOUND''' | ||
| + | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1IDO is a [ | + | 1IDO is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IDO OCA]. |
==Reference== | ==Reference== | ||
| - | Crystal structure of the A domain from the alpha subunit of integrin CR3 (CD11b/CD18)., Lee JO, Rieu P, Arnaout MA, Liddington R, Cell. 1995 Feb 24;80(4):631-8. PMID:[http:// | + | Crystal structure of the A domain from the alpha subunit of integrin CR3 (CD11b/CD18)., Lee JO, Rieu P, Arnaout MA, Liddington R, Cell. 1995 Feb 24;80(4):631-8. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/7867070 7867070] |
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
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[[Category: integrin]] | [[Category: integrin]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 11:48:59 2008'' |
Revision as of 09:49, 20 March 2008
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| , resolution 1.7Å | |||||||
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| Coordinates: | save as pdb, mmCIF, xml | ||||||
I-DOMAIN FROM INTEGRIN CR3, MG2+ BOUND
Overview
We have determined the high resolution crystal structure of the A domain from the alpha chain of integrin CR3. The domain adopts a classic alpha/beta "Rossmann" fold and contains an unusual Mg2+ coordination site at its surface. One of the coordinating ligands is the glutamate side chain from another A domain molecule. We suggest that this site represents a general metal ion-dependent adhesion site (MIDAS) for binding protein ligands. We further propose that the beta subunits of integrins contain a MIDAS motif within a modified A domain. Our crystal structure will allow reliable models to be built for other members of the A domain superfamily and should facilitate development of novel adhesion modulatory drugs.
About this Structure
1IDO is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Crystal structure of the A domain from the alpha subunit of integrin CR3 (CD11b/CD18)., Lee JO, Rieu P, Arnaout MA, Liddington R, Cell. 1995 Feb 24;80(4):631-8. PMID:7867070
Page seeded by OCA on Thu Mar 20 11:48:59 2008
