1ig7

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[[Image:1ig7.gif|left|200px]]<br /><applet load="1ig7" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:1ig7.gif|left|200px]]
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caption="1ig7, resolution 2.20&Aring;" />
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'''Msx-1 Homeodomain/DNA Complex Structure'''<br />
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{{Structure
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|PDB= 1ig7 |SIZE=350|CAPTION= <scene name='initialview01'>1ig7</scene>, resolution 2.20&Aring;
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|SITE=
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|LIGAND=
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|ACTIVITY=
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|GENE=
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}}
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'''Msx-1 Homeodomain/DNA Complex Structure'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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1IG7 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IG7 OCA].
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1IG7 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IG7 OCA].
==Reference==
==Reference==
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Crystal structure of the Msx-1 homeodomain/DNA complex., Hovde S, Abate-Shen C, Geiger JH, Biochemistry. 2001 Oct 9;40(40):12013-21. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=11580277 11580277]
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Crystal structure of the Msx-1 homeodomain/DNA complex., Hovde S, Abate-Shen C, Geiger JH, Biochemistry. 2001 Oct 9;40(40):12013-21. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11580277 11580277]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: helix-turn-helix]]
[[Category: helix-turn-helix]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 13:11:31 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 11:49:57 2008''

Revision as of 09:50, 20 March 2008

Image:1ig7.gif


PDB ID 1ig7

Drag the structure with the mouse to rotate
, resolution 2.20Å
Coordinates: save as pdb, mmCIF, xml



Msx-1 Homeodomain/DNA Complex Structure


Overview

The Msx-1 homeodomain protein plays a crucial role in craniofacial, limb, and nervous system development. Homeodomain DNA-binding domains are comprised of 60 amino acids that show a high degree of evolutionary conservation. We have determined the structure of the Msx-1 homeodomain complexed to DNA at 2.2 A resolution. The structure has an unusually well-ordered N-terminal arm with a unique trajectory across the minor groove of the DNA. DNA specificity conferred by bases flanking the core TAAT sequence is explained by well ordered water-mediated interactions at Q50. Most interactions seen at the TAAT sequence are typical of the interactions seen in other homeodomain structures. Comparison of the Msx-1-HD structure to all other high resolution HD-DNA complex structures indicate a remarkably well-conserved sphere of hydration between the DNA and protein in these complexes.

About this Structure

1IG7 is a Single protein structure of sequence from Mus musculus. Full crystallographic information is available from OCA.

Reference

Crystal structure of the Msx-1 homeodomain/DNA complex., Hovde S, Abate-Shen C, Geiger JH, Biochemistry. 2001 Oct 9;40(40):12013-21. PMID:11580277

Page seeded by OCA on Thu Mar 20 11:49:57 2008

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