1iie
From Proteopedia
| Line 1: | Line 1: | ||
| - | [[Image:1iie.gif|left|200px]] | + | [[Image:1iie.gif|left|200px]] |
| - | + | ||
| - | '''HLA-DR ANTIGENS ASSOCIATED INVARIANT CHAIN''' | + | {{Structure |
| + | |PDB= 1iie |SIZE=350|CAPTION= <scene name='initialview01'>1iie</scene> | ||
| + | |SITE= | ||
| + | |LIGAND= | ||
| + | |ACTIVITY= | ||
| + | |GENE= CD74 OR DHLAG ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]) | ||
| + | }} | ||
| + | |||
| + | '''HLA-DR ANTIGENS ASSOCIATED INVARIANT CHAIN''' | ||
| + | |||
==Overview== | ==Overview== | ||
| Line 7: | Line 16: | ||
==About this Structure== | ==About this Structure== | ||
| - | 1IIE is a [ | + | 1IIE is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IIE OCA]. |
==Reference== | ==Reference== | ||
| - | Structure of a trimeric domain of the MHC class II-associated chaperonin and targeting protein Ii., Jasanoff A, Wagner G, Wiley DC, EMBO J. 1998 Dec 1;17(23):6812-8. PMID:[http:// | + | Structure of a trimeric domain of the MHC class II-associated chaperonin and targeting protein Ii., Jasanoff A, Wagner G, Wiley DC, EMBO J. 1998 Dec 1;17(23):6812-8. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9843486 9843486] |
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
| Line 21: | Line 30: | ||
[[Category: oligomerization]] | [[Category: oligomerization]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 11:50:49 2008'' |
Revision as of 09:50, 20 March 2008
| |||||||
| Gene: | CD74 OR DHLAG (Homo sapiens) | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
HLA-DR ANTIGENS ASSOCIATED INVARIANT CHAIN
Overview
The invariant chain (Ii) plays a critical role in MHC class II antigen processing by stabilizing peptide-free class II alphabeta heterodimers in a nonameric (alphabetaIi)3 complex soon after their synthesis and directing transport of the complex from the endoplasmic reticulum to compartments where peptide loading of class II takes place. Loading progresses following Ii proteolysis and via an intermediate complex of MHC class II with an Ii-derived peptide, CLIP. CLIP is substituted by exogenous peptidic fragments in an exchange reaction catalyzed by HLA-DM. The CLIP region of Ii, roughly residues 81-104, is one of two segments shown to interact with class II HLA-DR molecules. The other segment, Ii 118-216, is C-terminal to CLIP, mediates trimerization of the ectodomain of Ii and interferes with DM/class II binding. Here we report the three-dimensional structure of this trimeric domain, determined by nuclear magnetic resonance (NMR) studies of a 27 kDa trimer of human Ii 118-192. The cylindrical shape of the molecule and the mapping of conserved residues delimit surfaces which may be important for interactions between Ii and class II molecules.
About this Structure
1IIE is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Structure of a trimeric domain of the MHC class II-associated chaperonin and targeting protein Ii., Jasanoff A, Wagner G, Wiley DC, EMBO J. 1998 Dec 1;17(23):6812-8. PMID:9843486
Page seeded by OCA on Thu Mar 20 11:50:49 2008
