We apologize for Proteopedia being slow to respond. For the past two years, a new implementation of Proteopedia has been being built. Soon, it will replace this 18-year old system. All existing content will be moved to the new system at a date that will be announced here.

2wro

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
{{Large structure}}
+
==THE CRYSTAL STRUCTURE OF THE 70S RIBOSOME BOUND TO EF-TU AND TRNA (PART 2 OF 4).==
-
{{STRUCTURE_2wro| PDB=2wro | SCENE= }}
+
<StructureSection load='2wro' size='340' side='right' caption='[[2wro]], [[Resolution|resolution]] 3.60&Aring;' scene=''>
-
===THE CRYSTAL STRUCTURE OF THE 70S RIBOSOME BOUND TO EF-TU AND TRNA (PART 2 OF 4).===
+
== Structural highlights ==
-
{{ABSTRACT_PUBMED_19833920}}
+
<table><tr><td colspan='2'>[[2wro]] is a 32 chain structure with sequence from [http://en.wikipedia.org/wiki/Thermus_thermophilus Thermus thermophilus]. The January 2010 RCSB PDB [http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''70S Ribosomes'' by David Goodsell is [http://dx.doi.org/10.2210/rcsb_pdb/mom_2010_1 10.2210/rcsb_pdb/mom_2010_1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WRO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2WRO FirstGlance]. <br>
 +
</td></tr><tr><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=UNK:UNKNOWN'>UNK</scene></td></tr>
 +
<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2wrn|2wrn]], [[2wrq|2wrq]], [[2wrr|2wrr]], [[2wdi|2wdi]], [[2v47|2v47]], [[2wh4|2wh4]], [[2jl6|2jl6]], [[2wh2|2wh2]], [[2wdl|2wdl]], [[2b9p|2b9p]], [[1yl3|1yl3]], [[2v49|2v49]], [[1giy|1giy]], [[2jl8|2jl8]], [[2b66|2b66]], [[1v8q|1v8q]], [[2j03|2j03]], [[2j01|2j01]], [[2wdn|2wdn]], [[1gd8|1gd8]], [[1wki|1wki]], [[2b9n|2b9n]], [[2wdj|2wdj]]</td></tr>
 +
<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2wro FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wro OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2wro RCSB], [http://www.ebi.ac.uk/pdbsum/2wro PDBsum]</span></td></tr>
 +
<table>
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wr/2wro_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
 +
<div style="clear:both"></div>
 +
<div style="background-color:#fffaf0;">
 +
== Publication Abstract from PubMed ==
 +
The ribosome selects a correct transfer RNA (tRNA) for each amino acid added to the polypeptide chain, as directed by messenger RNA (mRNA). Aminoacyl-tRNA is delivered to the ribosome by elongation factor Tu (EF-Tu), which hydrolyzes guanosine triphosphate (GTP) and releases tRNA in response to codon recognition. The signaling pathway that leads to GTP hydrolysis upon codon recognition is critical to accurate decoding. Here, we present the crystal structure of the ribosome complexed with EF-Tu and aminoacyl-tRNA, refined to 3.6 angstrom resolution. The structure reveals details of the tRNA distortion that allows aminoacyl-tRNA to interact simultaneously with the decoding center of the 30S subunit and EF-Tu at the factor-binding site. A series of conformational changes in EF-Tu and aminoacyl-tRNA suggest a communication pathway between the decoding center and the guanosine triphosphatase center of EF-Tu.
-
==About this Structure==
+
The Crystal Structure of the Ribosome Bound to EF-Tu and Aminoacyl-tRNA.,Schmeing TM, Voorhees RM, Kelley AC, Gao YG, Murphy FV 4th, Weir JR, Ramakrishnan V Science. 2009 Oct 15. PMID:19833920<ref>PMID:19833920</ref>
-
[[2wro]] is a 32 chain structure with sequence from [http://en.wikipedia.org/wiki/Thermus_thermophilus Thermus thermophilus]. The January 2010 RCSB PDB [http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''70S Ribosomes'' by David Goodsell is [http://dx.doi.org/10.2210/rcsb_pdb/mom_2010_1 10.2210/rcsb_pdb/mom_2010_1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WRO OCA].
+
-
==See Also==
+
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-
*[[Ribosomal protein L1|Ribosomal protein L1]]
+
</div>
-
*[[Ribosomal protein L10|Ribosomal protein L10]]
+
-
*[[Ribosomal protein L11|Ribosomal protein L11]]
+
-
*[[Ribosomal protein L13|Ribosomal protein L13]]
+
-
*[[Ribosomal protein L14|Ribosomal protein L14]]
+
-
*[[Ribosomal protein L15|Ribosomal protein L15]]
+
-
*[[Ribosomal protein L16|Ribosomal protein L16]]
+
-
*[[Ribosomal protein L17|Ribosomal protein L17]]
+
-
*[[Ribosomal protein L18|Ribosomal protein L18]]
+
-
*[[Ribosomal protein L19|Ribosomal protein L19]]
+
-
*[[Ribosomal protein L2|Ribosomal protein L2]]
+
-
*[[Ribosomal protein L20|Ribosomal protein L20]]
+
-
*[[Ribosomal protein L21|Ribosomal protein L21]]
+
-
*[[Ribosomal protein L22|Ribosomal protein L22]]
+
-
*[[Ribosomal protein L23|Ribosomal protein L23]]
+
-
*[[Ribosomal protein L24|Ribosomal protein L24]]
+
-
*[[Ribosomal protein L25|Ribosomal protein L25]]
+
-
*[[Ribosomal protein L27|Ribosomal protein L27]]
+
-
*[[Ribosomal protein L28|Ribosomal protein L28]]
+
-
*[[Ribosomal protein L29|Ribosomal protein L29]]
+
-
*[[Ribosomal protein L3|Ribosomal protein L3]]
+
-
*[[Ribosomal protein L30|Ribosomal protein L30]]
+
-
*[[Ribosomal protein L31|Ribosomal protein L31]]
+
-
*[[Ribosomal protein L32|Ribosomal protein L32]]
+
-
*[[Ribosomal protein L33|Ribosomal protein L33]]
+
-
*[[Ribosomal protein L34|Ribosomal protein L34]]
+
-
*[[Ribosomal protein L35|Ribosomal protein L35]]
+
-
*[[Ribosomal protein L36|Ribosomal protein L36]]
+
-
*[[Ribosomal protein L4|Ribosomal protein L4]]
+
-
*[[Ribosomal protein L5|Ribosomal protein L5]]
+
-
*[[Ribosomal protein L6|Ribosomal protein L6]]
+
-
*[[Ribosome|Ribosome]]
+
-
==Reference==
+
==See Also==
-
<ref group="xtra">PMID:019833920</ref><references group="xtra"/>
+
*[[Ribosome 3D structures|Ribosome 3D structures]]
 +
== References ==
 +
<references/>
 +
__TOC__
 +
</StructureSection>
[[Category: 70S Ribosomes]]
[[Category: 70S Ribosomes]]
[[Category: RCSB PDB Molecule of the Month]]
[[Category: RCSB PDB Molecule of the Month]]

Revision as of 01:47, 1 October 2014

THE CRYSTAL STRUCTURE OF THE 70S RIBOSOME BOUND TO EF-TU AND TRNA (PART 2 OF 4).

2wro, resolution 3.60Å

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2wro"
Views
Personal tools
Navigation
Toolbox