2x09

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[[Image:2x09.png|left|200px]]
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==INHIBITION OF THE EXO-BETA-D-GLUCOSAMINIDASE CSXA BY A GLUCOSAMINE-CONFIGURED CASTANOSPERMINE AND AN AMINO-AUSTRALINE ANALOGUE==
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<StructureSection load='2x09' size='340' side='right' caption='[[2x09]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2x09]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Amycolatopsis_orientalis Amycolatopsis orientalis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X09 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2X09 FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>, <scene name='pdbligand=X09:AMINO-AUSTRALINE'>X09</scene><br>
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<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2x05|2x05]], [[2vzr|2vzr]], [[2vzu|2vzu]], [[2vzs|2vzs]], [[2vzt|2vzt]], [[2vzo|2vzo]], [[2vzq|2vzq]], [[2vzp|2vzp]], [[2vzv|2vzv]]</td></tr>
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<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Exo-1,4-beta-D-glucosaminidase Exo-1,4-beta-D-glucosaminidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.165 3.2.1.165] </span></td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2x09 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2x09 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2x09 RCSB], [http://www.ebi.ac.uk/pdbsum/2x09 PDBsum]</span></td></tr>
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<table>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/x0/2x09_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The synthesis of amino-derivatives of castanospermine and australine and their characterisation as inhibitors of the exo-beta-D-glucosaminidase CsxA through enzyme kinetics and X-ray structural analysis is described.
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{{STRUCTURE_2x09| PDB=2x09 | SCENE= }}
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Inhibition of the exo-beta-D-glucosaminidase CsxA by a glucosamine-configured castanospermine and an amino-australine analogue.,Pluvinage B, Ghinet MG, Brzezinski R, Boraston AB, Stubbs KA Org Biomol Chem. 2009 Oct 21;7(20):4169-72. Epub 2009 Aug 14. PMID:19795054<ref>PMID:19795054</ref>
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===INHIBITION OF THE EXO-BETA-D-GLUCOSAMINIDASE CSXA BY A GLUCOSAMINE-CONFIGURED CASTANOSPERMINE AND AN AMINO-AUSTRALINE ANALOGUE===
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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{{ABSTRACT_PUBMED_19795054}}
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== References ==
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<references/>
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==About this Structure==
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__TOC__
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[[2x09]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Amycolatopsis_orientalis Amycolatopsis orientalis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X09 OCA].
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</StructureSection>
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==Reference==
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<ref group="xtra">PMID:019795054</ref><references group="xtra"/>
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[[Category: Amycolatopsis orientalis]]
[[Category: Amycolatopsis orientalis]]
[[Category: Exo-1,4-beta-D-glucosaminidase]]
[[Category: Exo-1,4-beta-D-glucosaminidase]]

Revision as of 01:49, 1 October 2014

INHIBITION OF THE EXO-BETA-D-GLUCOSAMINIDASE CSXA BY A GLUCOSAMINE-CONFIGURED CASTANOSPERMINE AND AN AMINO-AUSTRALINE ANALOGUE

2x09, resolution 2.40Å

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OCA

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