1ijv
From Proteopedia
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| - | [[Image:1ijv.jpg|left|200px]] | + | [[Image:1ijv.jpg|left|200px]] |
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| - | '''HUMAN BETA-DEFENSIN-1''' | + | {{Structure |
| + | |PDB= 1ijv |SIZE=350|CAPTION= <scene name='initialview01'>1ijv</scene>, resolution 1.20Å | ||
| + | |SITE= | ||
| + | |LIGAND= <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=BR:BROMIDE+ION'>BR</scene> and <scene name='pdbligand=K:POTASSIUM ION'>K</scene> | ||
| + | |ACTIVITY= | ||
| + | |GENE= | ||
| + | }} | ||
| + | |||
| + | '''HUMAN BETA-DEFENSIN-1''' | ||
| + | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1IJV is a [ | + | 1IJV is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IJV OCA]. |
==Reference== | ==Reference== | ||
| - | The structure of human beta-defensin-1: new insights into structural properties of beta-defensins., Hoover DM, Chertov O, Lubkowski J, J Biol Chem. 2001 Oct 19;276(42):39021-6. Epub 2001 Aug 2. PMID:[http:// | + | The structure of human beta-defensin-1: new insights into structural properties of beta-defensins., Hoover DM, Chertov O, Lubkowski J, J Biol Chem. 2001 Oct 19;276(42):39021-6. Epub 2001 Aug 2. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11486002 11486002] |
[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Hoover, D M.]] | [[Category: Hoover, D M.]] | ||
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[[Category: human beta-defensin-1]] | [[Category: human beta-defensin-1]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 11:51:19 2008'' |
Revision as of 09:51, 20 March 2008
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| , resolution 1.20Å | |||||||
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| Ligands: | , and | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
HUMAN BETA-DEFENSIN-1
Overview
Defensins are a class of small cationic peptides found in higher organisms that serve as both antimicrobial and cell signaling molecules. The exact mechanism of the antimicrobial activity of defensins is not known, but two models have been postulated, one involving pore formation and the other involving nonspecific electrostatic interaction with the bacterial membrane. Here we report the high resolution structures of human beta-defensin-1 (hBD1) in two crystallographic space groups. The structure of a single molecule is very similar to that of human beta-defensin-2 (hBD2), confirming the presence of an N-terminal alpha-helix. However, while the packing of hBD1 is conserved across both space groups, there is no evidence for any larger quaternary structure similar to octameric hBD2. Furthermore, the topology of hBD1 dimers that are formed between monomers in the asymmetric unit is distinct from both hBD2 and other mammalian alpha-defensins. The structures of hBD1 and hBD2 provide a first step toward understanding the structural basis of antimicrobial and chemotactic properties of human beta-defensins.
About this Structure
1IJV is a Single protein structure of sequence from [1]. Full crystallographic information is available from OCA.
Reference
The structure of human beta-defensin-1: new insights into structural properties of beta-defensins., Hoover DM, Chertov O, Lubkowski J, J Biol Chem. 2001 Oct 19;276(42):39021-6. Epub 2001 Aug 2. PMID:11486002
Page seeded by OCA on Thu Mar 20 11:51:19 2008
Categories: Single protein | Hoover, D M. | Lubkowski, J. | BR | K | SO4 | Beta-defensin | Defensin | Human beta-defensin-1
