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2wh1

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{{STRUCTURE_2wh1| PDB=2wh1 | SCENE= }}
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==INSIGHTS INTO TRANSLATIONAL TERMINATION FROM THE STRUCTURE OF RF2 BOUND TO THE RIBOSOME==
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===INSIGHTS INTO TRANSLATIONAL TERMINATION FROM THE STRUCTURE OF RF2 BOUND TO THE RIBOSOME===
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<StructureSection load='2wh1' size='340' side='right' caption='[[2wh1]], [[Resolution|resolution]] 3.45&Aring;' scene=''>
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{{ABSTRACT_PUBMED_18988853}}
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2wh1]] is a 25 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] and [http://en.wikipedia.org/wiki/Thermus_thermophilus Thermus thermophilus]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=2jl5 2jl5]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WH1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2WH1 FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene><br>
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<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2wh2|2wh2]], [[2wh3|2wh3]], [[2wh4|2wh4]], [[1hr0|1hr0]], [[2v48|2v48]], [[1ibk|1ibk]], [[2b64|2b64]], [[1xmq|1xmq]], [[1ibl|1ibl]], [[2b9m|2b9m]], [[2uuc|2uuc]], [[2wdk|2wdk]], [[1pn8|1pn8]], [[2wdg|2wdg]], [[1xnr|1xnr]], [[1dv4|1dv4]], [[1hnz|1hnz]], [[1rss|1rss]], [[2wdh|2wdh]], [[2j02|2j02]], [[1j5e|1j5e]], [[1jgq|1jgq]], [[2j00|2j00]], [[2b9o|2b9o]], [[1i94|1i94]], [[1hnx|1hnx]], [[1i96|1i96]], [[2uu9|2uu9]], [[1pn7|1pn7]], [[2uub|2uub]], [[1vov|1vov]], [[1eg0|1eg0]], [[1ibm|1ibm]], [[1emi|1emi]], [[2uxb|2uxb]], [[2vqe|2vqe]], [[1g1x|1g1x]], [[1pnx|1pnx]], [[2v46|2v46]], [[2uua|2uua]], [[1i95|1i95]], [[1xnq|1xnq]], [[1qd7|1qd7]], [[2vqf|2vqf]], [[1gix|1gix]], [[1jgo|1jgo]], [[1jgp|1jgp]], [[1n32|1n32]], [[2f4v|2f4v]], [[1n34|1n34]], [[1n33|1n33]], [[1twt|1twt]], [[1pns|1pns]], [[1qzc|1qzc]], [[2uxd|2uxd]], [[1fka|1fka]], [[1yl4|1yl4]], [[2wdm|2wdm]], [[2uxc|2uxc]], [[1n36|1n36]], [[1fjg|1fjg]], [[1xmo|1xmo]], [[1hnw|1hnw]], [[1i97|1i97]], [[1l1u|1l1u]]</td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2wh1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wh1 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2wh1 RCSB], [http://www.ebi.ac.uk/pdbsum/2wh1 PDBsum]</span></td></tr>
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<table>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wh/2wh1_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The termination of protein synthesis occurs through the specific recognition of a stop codon in the A site of the ribosome by a release factor (RF), which then catalyzes the hydrolysis of the nascent protein chain from the P-site transfer RNA. Here we present, at a resolution of 3.5 angstroms, the crystal structure of RF2 in complex with its cognate UGA stop codon in the 70S ribosome. The structure provides insight into how RF2 specifically recognizes the stop codon; it also suggests a model for the role of a universally conserved GGQ motif in the catalysis of peptide release.
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==About this Structure==
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Insights into translational termination from the structure of RF2 bound to the ribosome.,Weixlbaumer A, Jin H, Neubauer C, Voorhees RM, Petry S, Kelley AC, Ramakrishnan V Science. 2008 Nov 7;322(5903):953-6. PMID:18988853<ref>PMID:18988853</ref>
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[[2wh1]] is a 25 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] and [http://en.wikipedia.org/wiki/Thermus_thermophilus Thermus thermophilus]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=2jl5 2jl5]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WH1 OCA].
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
==See Also==
==See Also==
*[[Kink-turn motif|Kink-turn motif]]
*[[Kink-turn motif|Kink-turn motif]]
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*[[Ribosomal protein S10|Ribosomal protein S10]]
 
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*[[Ribosomal protein S11|Ribosomal protein S11]]
 
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*[[Ribosomal protein S12|Ribosomal protein S12]]
 
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*[[Ribosomal protein S13|Ribosomal protein S13]]
 
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*[[Ribosomal protein S14|Ribosomal protein S14]]
 
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*[[Ribosomal protein S15|Ribosomal protein S15]]
 
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*[[Ribosomal protein S16|Ribosomal protein S16]]
 
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*[[Ribosomal protein S17|Ribosomal protein S17]]
 
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*[[Ribosomal protein S18|Ribosomal protein S18]]
 
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*[[Ribosomal protein S19|Ribosomal protein S19]]
 
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*[[Ribosomal protein S2|Ribosomal protein S2]]
 
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*[[Ribosomal protein S20|Ribosomal protein S20]]
 
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*[[Ribosomal protein S3|Ribosomal protein S3]]
 
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*[[Ribosomal protein S4|Ribosomal protein S4]]
 
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*[[Ribosomal protein S5|Ribosomal protein S5]]
 
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*[[Ribosomal protein S6|Ribosomal protein S6]]
 
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*[[Ribosomal protein S7|Ribosomal protein S7]]
 
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*[[Ribosomal protein S8|Ribosomal protein S8]]
 
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*[[Ribosomal protein S9|Ribosomal protein S9]]
 
*[[Ribosomal protein THX|Ribosomal protein THX]]
*[[Ribosomal protein THX|Ribosomal protein THX]]
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*[[Ribosome 3D structures|Ribosome 3D structures]]
*[[User:Wayne Decatur/kink-turn motif|User:Wayne Decatur/kink-turn motif]]
*[[User:Wayne Decatur/kink-turn motif|User:Wayne Decatur/kink-turn motif]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:018988853</ref><references group="xtra"/>
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__TOC__
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</StructureSection>
[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
[[Category: Thermus thermophilus]]
[[Category: Thermus thermophilus]]

Revision as of 02:14, 1 October 2014

INSIGHTS INTO TRANSLATIONAL TERMINATION FROM THE STRUCTURE OF RF2 BOUND TO THE RIBOSOME

2wh1, resolution 3.45Å

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