We apologize for Proteopedia being slow to respond. For the past two years, a new implementation of Proteopedia has been being built. Soon, it will replace this 18-year old system. All existing content will be moved to the new system at a date that will be announced here.

2vw9

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
m (Protected "2vw9" [edit=sysop:move=sysop])
Line 1: Line 1:
-
[[Image:2vw9.png|left|200px]]
+
==SINGLE STRANDED DNA BINDING PROTEIN COMPLEX FROM HELICOBACTER PYLORI==
 +
<StructureSection load='2vw9' size='340' side='right' caption='[[2vw9]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
 +
== Structural highlights ==
 +
<table><tr><td colspan='2'>[[2vw9]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Helicobacter_pylori Helicobacter pylori]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VW9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2VW9 FirstGlance]. <br>
 +
</td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vw9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vw9 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2vw9 RCSB], [http://www.ebi.ac.uk/pdbsum/2vw9 PDBsum]</span></td></tr>
 +
<table>
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vw/2vw9_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
 +
<div style="clear:both"></div>
 +
<div style="background-color:#fffaf0;">
 +
== Publication Abstract from PubMed ==
 +
Single-stranded DNA (ssDNA)-binding protein (SSB) plays an important role in DNA replication, recombination, and repair. SSB consists of an N-terminal ssDNA-binding domain with an oligonucleotide/oligosaccharide binding fold and a flexible C-terminal tail involved in protein-protein interactions. SSB from Helicobacter pylori (HpSSB) was isolated, and the ssDNA-binding characteristics of HpSSB were analyzed by fluorescence titration and electrophoretic mobility shift assay. Tryptophan fluorescence quenching was measured as 61%, and the calculated cooperative affinity was 5.4x10(7) M(-1) with an ssDNA-binding length of 25-30 nt. The crystal structure of the C-terminally truncated protein (HpSSBc) in complex with 35-mer ssDNA [HpSSBc-(dT)(35)] was determined at a resolution of 2.3 A. The HpSSBc monomer folds as an oligonucleotide/oligosaccharide binding fold with a Y-shaped conformation. The ssDNA wrapped around the HpSSBc tetramer through a continuous binding path comprising five essential aromatic residues and a positively charged surface formed by numerous basic residues.
-
{{STRUCTURE_2vw9| PDB=2vw9 | SCENE= }}
+
Single-stranded DNA-binding protein complex from Helicobacter pylori suggests an ssDNA-binding surface.,Chan KW, Lee YJ, Wang CH, Huang H, Sun YJ J Mol Biol. 2009 May 8;388(3):508-19. Epub 2009 Mar 13. PMID:19285993<ref>PMID:19285993</ref>
-
===SINGLE STRANDED DNA BINDING PROTEIN COMPLEX FROM HELICOBACTER PYLORI===
+
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
 +
</div>
-
{{ABSTRACT_PUBMED_19285993}}
+
==See Also==
-
 
+
*[[Single stranded binding protein|Single stranded binding protein]]
-
==About this Structure==
+
*[[Single-stranded DNA-binding protein|Single-stranded DNA-binding protein]]
-
[[2vw9]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Helicobacter_pylori Helicobacter pylori]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VW9 OCA].
+
== References ==
-
 
+
<references/>
-
==Reference==
+
__TOC__
-
<ref group="xtra">PMID:019285993</ref><references group="xtra"/>
+
</StructureSection>
[[Category: Helicobacter pylori]]
[[Category: Helicobacter pylori]]
[[Category: Chan, K W.]]
[[Category: Chan, K W.]]

Revision as of 02:15, 1 October 2014

SINGLE STRANDED DNA BINDING PROTEIN COMPLEX FROM HELICOBACTER PYLORI

2vw9, resolution 2.30Å

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2vw9"
Views
Personal tools
Navigation
Toolbox