2v9b

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[[Image:2v9b.png|left|200px]]
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==X-RAY STRUCTURE OF VISCOTOXIN B2 FROM VISCUM ALBUM==
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<StructureSection load='2v9b' size='340' side='right' caption='[[2v9b]], [[Resolution|resolution]] 1.05&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2v9b]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Viscum_album Viscum album]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V9B OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2V9B FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene><br>
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<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1jmp|1jmp]], [[1orl|1orl]]</td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2v9b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2v9b OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2v9b RCSB], [http://www.ebi.ac.uk/pdbsum/2v9b PDBsum]</span></td></tr>
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<table>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/v9/2v9b_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Crystals of the cytotoxic thionin proteins viscotoxins A1 and B2 extracted from mistletoe diffracted to high resolution (1.25 and 1.05 A, respectively) and are excellent candidates for testing crystallographic methods. Ab initio direct methods were only successful in solving the viscotoxin B2 structure, which with 861 unique non-H atoms is one of the largest unknown structures without an atom heavier than sulfur to be solved in this way, but sulfur-SAD phasing provided a convincing solution for viscotoxin A1. Both proteins form dimers in the crystal and viscotoxin B2 (net charge +4 per monomer), but not viscotoxin A1 (net charge +6), is coordinated by sulfate or phosphate anions. The viscotoxin A1 crystal has a higher solvent content than the viscotoxin B2 crystal (49% as opposed to 28%) with solvent channels along the crystallographic 4(3) axes.
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{{STRUCTURE_2v9b| PDB=2v9b | SCENE= }}
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Structures of viscotoxins A1 and B2 from European mistletoe solved using native data alone.,Pal A, Debreczeni JE, Sevvana M, Gruene T, Kahle B, Zeeck A, Sheldrick GM Acta Crystallogr D Biol Crystallogr. 2008 Sep;64(Pt 9):985-92. Epub 2008, Aug 13. PMID:18703848<ref>PMID:18703848</ref>
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===X-RAY STRUCTURE OF VISCOTOXIN B2 FROM VISCUM ALBUM===
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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{{ABSTRACT_PUBMED_18703848}}
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== References ==
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<references/>
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==About this Structure==
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__TOC__
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[[2v9b]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Viscum_album Viscum album]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V9B OCA].
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</StructureSection>
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==Reference==
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<ref group="xtra">PMID:018703848</ref><references group="xtra"/>
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[[Category: Viscum album]]
[[Category: Viscum album]]
[[Category: Debreczeni, J E.]]
[[Category: Debreczeni, J E.]]

Revision as of 02:16, 1 October 2014

X-RAY STRUCTURE OF VISCOTOXIN B2 FROM VISCUM ALBUM

2v9b, resolution 1.05Å

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