2xdg

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[[Image:2xdg.png|left|200px]]
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==CRYSTAL STRUCTURE OF THE EXTRACELLULAR DOMAIN OF HUMAN GROWTH HORMONE RELEASING HORMONE RECEPTOR.==
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<StructureSection load='2xdg' size='340' side='right' caption='[[2xdg]], [[Resolution|resolution]] 1.95&Aring;' scene=''>
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{{STRUCTURE_2xdg| PDB=2xdg | SCENE= }}
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2xdg]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XDG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2XDG FirstGlance]. <br>
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===CRYSTAL STRUCTURE OF THE EXTRACELLULAR DOMAIN OF HUMAN GROWTH HORMONE RELEASING HORMONE RECEPTOR.===
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</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene><br>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2xdg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xdg OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2xdg RCSB], [http://www.ebi.ac.uk/pdbsum/2xdg PDBsum]</span></td></tr>
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<table>
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==About this Structure==
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== Disease ==
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[[2xdg]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XDG OCA].
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[[http://www.uniprot.org/uniprot/GHRHR_HUMAN GHRHR_HUMAN]] Isolated growth hormone deficiency type IB. The disease is caused by mutations affecting the gene represented in this entry.<ref>PMID:11232012</ref> <ref>PMID:10084571</ref> <ref>PMID:12534354</ref>
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== Function ==
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[[http://www.uniprot.org/uniprot/GHRHR_HUMAN GHRHR_HUMAN]] Receptor for GRF, coupled to G proteins which activate adenylyl cyclase. Stimulates somatotroph cell growth, growth hormone gene transcription and growth hormone secretion.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/xd/2xdg_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
*[[Hormone|Hormone]]
*[[Hormone|Hormone]]
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Arrowsmith, C H.]]
[[Category: Arrowsmith, C H.]]

Revision as of 00:57, 2 October 2014

CRYSTAL STRUCTURE OF THE EXTRACELLULAR DOMAIN OF HUMAN GROWTH HORMONE RELEASING HORMONE RECEPTOR.

2xdg, resolution 1.95Å

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