2l8k
From Proteopedia
(Difference between revisions)
| Line 1: | Line 1: | ||
| - | [[ | + | ==NMR Structure of the Arterivirus nonstructural protein 7 alpha (nsp7 alpha)== |
| + | <StructureSection load='2l8k' size='340' side='right' caption='[[2l8k]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[2l8k]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Equine_arteritis_virus Equine arteritis virus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L8K OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2L8K FirstGlance]. <br> | ||
| + | </td></tr><tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">rep, 1a-1b ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=11047 Equine arteritis virus])</td></tr> | ||
| + | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2l8k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2l8k OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2l8k RCSB], [http://www.ebi.ac.uk/pdbsum/2l8k PDBsum]</span></td></tr> | ||
| + | <table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Arterivirus replicase polyproteins are cleaved into at least 13 mature nonstructural proteins (nsps), and in particular the nsp5-to-nsp8 region is subject to a complex processing cascade. The function of the largest subunit from this region, nsp7, which is further cleaved into nsp7alpha and nsp7beta, is unknown. Using nuclear magnetic resonance (NMR) spectroscopy, we determined the solution structure of nsp7alpha of equine arteritis virus, revealing an interesting unique fold for this protein but thereby providing little clue to its possible functions. Nevertheless, structure-based reverse genetics studies established the importance of nsp7/nsp7alpha for viral RNA synthesis, thus providing a basis for future studies. | ||
| - | { | + | Structure and Genetic Analysis of the Arterivirus Nonstructural Protein 7{alpha}.,Manolaridis I, Gaudin C, Posthuma CC, Zevenhoven-Dobbe JC, Imbert I, Canard B, Kelly G, Tucker PA, Conte MR, Snijder EJ J Virol. 2011 Jul;85(14):7449-53. Epub 2011 May 11. PMID:21561912<ref>PMID:21561912</ref> |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | + | </div> | |
| - | + | ||
| - | + | ||
| - | + | ||
| - | + | ||
==See Also== | ==See Also== | ||
*[[Nonstructural protein|Nonstructural protein]] | *[[Nonstructural protein|Nonstructural protein]] | ||
| - | + | == References == | |
| - | == | + | <references/> |
| - | < | + | __TOC__ |
| + | </StructureSection> | ||
[[Category: Equine arteritis virus]] | [[Category: Equine arteritis virus]] | ||
[[Category: Conte, M R.]] | [[Category: Conte, M R.]] | ||
Revision as of 01:01, 2 October 2014
NMR Structure of the Arterivirus nonstructural protein 7 alpha (nsp7 alpha)
| |||||||||||
