1iqo
From Proteopedia
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| - | [[Image:1iqo.jpg|left|200px]] | + | [[Image:1iqo.jpg|left|200px]] |
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| - | '''Solution structure of MTH1880 from methanobacterium thermoautotrophicum''' | + | {{Structure |
| + | |PDB= 1iqo |SIZE=350|CAPTION= <scene name='initialview01'>1iqo</scene> | ||
| + | |SITE= | ||
| + | |LIGAND= | ||
| + | |ACTIVITY= | ||
| + | |GENE= | ||
| + | }} | ||
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| + | '''Solution structure of MTH1880 from methanobacterium thermoautotrophicum''' | ||
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==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1IQO is a [ | + | 1IQO is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Methanothermobacter Methanothermobacter]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IQO OCA]. |
==Reference== | ==Reference== | ||
| - | Solution structure of a novel calcium binding protein, MTH1880, from Methanobacterium thermoautotrophicum., Lee CH, Jung JW, Yee A, Arrowsmith CH, Lee W, Protein Sci. 2004 Apr;13(4):1148-54. PMID:[http:// | + | Solution structure of a novel calcium binding protein, MTH1880, from Methanobacterium thermoautotrophicum., Lee CH, Jung JW, Yee A, Arrowsmith CH, Lee W, Protein Sci. 2004 Apr;13(4):1148-54. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15044740 15044740] |
[[Category: Methanothermobacter]] | [[Category: Methanothermobacter]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
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[[Category: beta-alpha]] | [[Category: beta-alpha]] | ||
[[Category: calcium binding]] | [[Category: calcium binding]] | ||
| - | [[Category: structural | + | [[Category: structural genomic]] |
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 11:53:37 2008'' |
Revision as of 09:53, 20 March 2008
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Solution structure of MTH1880 from methanobacterium thermoautotrophicum
Overview
MTH1880 is a hypothetical protein from Methanobacterium thermoautotrophicum, a target organism of structural genomics. The solution structure determined by NMR spectroscopy demonstrates a typical alpha + beta-fold found in many proteins with different functions. The molecular surface of the protein reveals a small, highly acidic pocket comprising loop B (Asp36, Asp37, Asp38), the end of beta2 (Glu39), and loop D (Ser57, Ser58, Ser61), indicating that the protein would have a possible cation binding site. The NMR resonances of several amino acids within the acidic binding pocket in MTH1880, shifted upon addition of calcium ion. This calcium binding motif and overall topology of MTH1880 differ from those of other calcium binding proteins. MTH1880 did not show a calcium-induced conformational change typical of calcium sensor proteins. Therefore, we propose that the MTH1880 protein contains a novel motif for calcium-specific binding, and may function as a calcium buffering protein.
About this Structure
1IQO is a Single protein structure of sequence from Methanothermobacter. Full crystallographic information is available from OCA.
Reference
Solution structure of a novel calcium binding protein, MTH1880, from Methanobacterium thermoautotrophicum., Lee CH, Jung JW, Yee A, Arrowsmith CH, Lee W, Protein Sci. 2004 Apr;13(4):1148-54. PMID:15044740
Page seeded by OCA on Thu Mar 20 11:53:37 2008
