2zjr

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{{Large structure}}
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==Refined native structure of the large ribosomal subunit (50S) from Deinococcus radiodurans==
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{{STRUCTURE_2zjr| PDB=2zjr | SCENE= }}
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<StructureSection load='2zjr' size='340' side='right' caption='[[2zjr]], [[Resolution|resolution]] 2.91&Aring;' scene=''>
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===Refined native structure of the large ribosomal subunit (50S) from Deinococcus radiodurans===
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== Structural highlights ==
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{{ABSTRACT_PUBMED_18406324}}
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<table><tr><td colspan='2'>[[2zjr]] is a 30 chain structure with sequence from [http://en.wikipedia.org/wiki/Deinococcus_radiodurans Deinococcus radiodurans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZJR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ZJR FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene><br>
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<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2zjq|2zjq]], [[2zjp|2zjp]], [[3cf5|3cf5]]</td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2zjr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zjr OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2zjr RCSB], [http://www.ebi.ac.uk/pdbsum/2zjr PDBsum]</span></td></tr>
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<table>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/zj/2zjr_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The thiopeptide class of antibiotics targets the GTPase-associated center (GAC) of the ribosome to inhibit translation factor function. Using X-ray crystallography, we have determined the binding sites of thiostrepton (Thio), nosiheptide (Nosi), and micrococcin (Micro), on the Deinococcus radiodurans large ribosomal subunit. The thiopeptides, by binding within a cleft located between the ribosomal protein L11 and helices 43 and 44 of the 23S rRNA, overlap with the position of domain V of EF-G, thus explaining how this class of drugs perturbs translation factor binding to the ribosome. The presence of Micro leads to additional density for the C-terminal domain (CTD) of L7, adjacent to and interacting with L11. The results suggest that L11 acts as a molecular switch to control L7 binding and plays a pivotal role in positioning one L7-CTD monomer on the G' subdomain of EF-G to regulate EF-G turnover during protein synthesis.
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==About this Structure==
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Translational regulation via L11: molecular switches on the ribosome turned on and off by thiostrepton and micrococcin.,Harms JM, Wilson DN, Schluenzen F, Connell SR, Stachelhaus T, Zaborowska Z, Spahn CM, Fucini P Mol Cell. 2008 Apr 11;30(1):26-38. PMID:18406324<ref>PMID:18406324</ref>
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[[2zjr]] is a 30 chain structure with sequence from [http://en.wikipedia.org/wiki/Deinococcus_radiodurans Deinococcus radiodurans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZJR OCA].
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
==See Also==
==See Also==
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*[[Ribosomal protein L11|Ribosomal protein L11]]
 
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*[[Ribosomal protein L13|Ribosomal protein L13]]
 
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*[[Ribosomal protein L14|Ribosomal protein L14]]
 
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*[[Ribosomal protein L15|Ribosomal protein L15]]
 
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*[[Ribosomal protein L16|Ribosomal protein L16]]
 
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*[[Ribosomal protein L17|Ribosomal protein L17]]
 
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*[[Ribosomal protein L18|Ribosomal protein L18]]
 
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*[[Ribosomal protein L19|Ribosomal protein L19]]
 
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*[[Ribosomal protein L2|Ribosomal protein L2]]
 
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*[[Ribosomal protein L20|Ribosomal protein L20]]
 
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*[[Ribosomal protein L21|Ribosomal protein L21]]
 
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*[[Ribosomal protein L22|Ribosomal protein L22]]
 
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*[[Ribosomal protein L23|Ribosomal protein L23]]
 
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*[[Ribosomal protein L24|Ribosomal protein L24]]
 
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*[[Ribosomal protein L25|Ribosomal protein L25]]
 
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*[[Ribosomal protein L27|Ribosomal protein L27]]
 
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*[[Ribosomal protein L28|Ribosomal protein L28]]
 
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*[[Ribosomal protein L29|Ribosomal protein L29]]
 
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*[[Ribosomal protein L3|Ribosomal protein L3]]
 
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*[[Ribosomal protein L30|Ribosomal protein L30]]
 
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*[[Ribosomal protein L32|Ribosomal protein L32]]
 
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*[[Ribosomal protein L33|Ribosomal protein L33]]
 
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*[[Ribosomal protein L34|Ribosomal protein L34]]
 
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*[[Ribosomal protein L35|Ribosomal protein L35]]
 
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*[[Ribosomal protein L36|Ribosomal protein L36]]
 
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*[[Ribosomal protein L4|Ribosomal protein L4]]
 
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*[[Ribosomal protein L5|Ribosomal protein L5]]
 
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*[[Ribosomal protein L6|Ribosomal protein L6]]
 
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*[[Ribosomal protein L7|Ribosomal protein L7]]
 
*[[Ribosome|Ribosome]]
*[[Ribosome|Ribosome]]
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*[[Ribosome 3D structures|Ribosome 3D structures]]
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==Reference==
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== References ==
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<ref group="xtra">PMID:018406324</ref><references group="xtra"/>
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<references/>
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__TOC__
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</StructureSection>
[[Category: Deinococcus radiodurans]]
[[Category: Deinococcus radiodurans]]
[[Category: Connell, S R.]]
[[Category: Connell, S R.]]

Revision as of 05:13, 2 October 2014

Refined native structure of the large ribosomal subunit (50S) from Deinococcus radiodurans

2zjr, resolution 2.91Å

Drag the structure with the mouse to rotate

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OCA

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