1itg
From Proteopedia
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| - | [[Image:1itg.gif|left|200px]] | + | [[Image:1itg.gif|left|200px]] |
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| - | '''CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF HIV-1 INTEGRASE: SIMILARITY TO OTHER POLYNUCLEOTIDYL TRANSFERASES''' | + | {{Structure |
| + | |PDB= 1itg |SIZE=350|CAPTION= <scene name='initialview01'>1itg</scene>, resolution 2.3Å | ||
| + | |SITE= | ||
| + | |LIGAND= <scene name='pdbligand=CAC:CACODYLATE ION'>CAC</scene> | ||
| + | |ACTIVITY= | ||
| + | |GENE= HIV-1 INTEGRASE ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=11676 Human immunodeficiency virus 1]) | ||
| + | }} | ||
| + | |||
| + | '''CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF HIV-1 INTEGRASE: SIMILARITY TO OTHER POLYNUCLEOTIDYL TRANSFERASES''' | ||
| + | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1ITG is a [ | + | 1ITG is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ITG OCA]. |
==Reference== | ==Reference== | ||
| - | Crystal structure of the catalytic domain of HIV-1 integrase: similarity to other polynucleotidyl transferases., Dyda F, Hickman AB, Jenkins TM, Engelman A, Craigie R, Davies DR, Science. 1994 Dec 23;266(5193):1981-6. PMID:[http:// | + | Crystal structure of the catalytic domain of HIV-1 integrase: similarity to other polynucleotidyl transferases., Dyda F, Hickman AB, Jenkins TM, Engelman A, Craigie R, Davies DR, Science. 1994 Dec 23;266(5193):1981-6. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/7801124 7801124] |
[[Category: Human immunodeficiency virus 1]] | [[Category: Human immunodeficiency virus 1]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
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[[Category: dna integration]] | [[Category: dna integration]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 11:54:43 2008'' |
Revision as of 09:54, 20 March 2008
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| , resolution 2.3Å | |||||||
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| Ligands: | |||||||
| Gene: | HIV-1 INTEGRASE (Human immunodeficiency virus 1) | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF HIV-1 INTEGRASE: SIMILARITY TO OTHER POLYNUCLEOTIDYL TRANSFERASES
Overview
HIV integrase is the enzyme responsible for inserting the viral DNA into the host chromosome; it is essential for HIV replication. The crystal structure of the catalytically active core domain (residues 50 to 212) of HIV-1 integrase was determined at 2.5 A resolution. The central feature of the structure is a five-stranded beta sheet flanked by helical regions. The overall topology reveals that this domain of integrase belongs to a superfamily of polynucleotidyl transferases that includes ribonuclease H and the Holliday junction resolvase RuvC. The active site region is identified by the position of two of the conserved carboxylate residues essential for catalysis, which are located at similar positions in ribonuclease H. In the crystal, two molecules form a dimer with a extensive solvent-inaccessible interface of 1300 A2 per monomer.
About this Structure
1ITG is a Single protein structure of sequence from Human immunodeficiency virus 1. Full crystallographic information is available from OCA.
Reference
Crystal structure of the catalytic domain of HIV-1 integrase: similarity to other polynucleotidyl transferases., Dyda F, Hickman AB, Jenkins TM, Engelman A, Craigie R, Davies DR, Science. 1994 Dec 23;266(5193):1981-6. PMID:7801124
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