1ivo

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[[Image:1ivo.gif|left|200px]]<br /><applet load="1ivo" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:1ivo.gif|left|200px]]
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caption="1ivo, resolution 3.30&Aring;" />
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'''Crystal Structure of the Complex of Human Epidermal Growth Factor and Receptor Extracellular Domains.'''<br />
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{{Structure
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|PDB= 1ivo |SIZE=350|CAPTION= <scene name='initialview01'>1ivo</scene>, resolution 3.30&Aring;
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|SITE=
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|LIGAND= <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>
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|ACTIVITY= [http://en.wikipedia.org/wiki/Transferase Transferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.10.1 and 2.7.10.2 2.7.10.1 and 2.7.10.2]
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|GENE=
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}}
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'''Crystal Structure of the Complex of Human Epidermal Growth Factor and Receptor Extracellular Domains.'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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1IVO is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=NAG:'>NAG</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Transferase Transferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.10.1 and 2.7.10.2 2.7.10.1 and 2.7.10.2] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IVO OCA].
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1IVO is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IVO OCA].
==Reference==
==Reference==
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Crystal structure of the complex of human epidermal growth factor and receptor extracellular domains., Ogiso H, Ishitani R, Nureki O, Fukai S, Yamanaka M, Kim JH, Saito K, Sakamoto A, Inoue M, Shirouzu M, Yokoyama S, Cell. 2002 Sep 20;110(6):775-87. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=12297050 12297050]
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Crystal structure of the complex of human epidermal growth factor and receptor extracellular domains., Ogiso H, Ishitani R, Nureki O, Fukai S, Yamanaka M, Kim JH, Saito K, Sakamoto A, Inoue M, Shirouzu M, Yokoyama S, Cell. 2002 Sep 20;110(6):775-87. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12297050 12297050]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Protein complex]]
[[Category: Protein complex]]
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[[Category: rsgi]]
[[Category: rsgi]]
[[Category: signal]]
[[Category: signal]]
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[[Category: structural genomics]]
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[[Category: structural genomic]]
[[Category: transmembrane]]
[[Category: transmembrane]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 13:16:07 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 11:55:30 2008''

Revision as of 09:55, 20 March 2008

Image:1ivo.gif


PDB ID 1ivo

Drag the structure with the mouse to rotate
, resolution 3.30Å
Ligands:
Activity: Transferase, with EC number and 2.7.10.2 2.7.10.1 and 2.7.10.2
Coordinates: save as pdb, mmCIF, xml



Crystal Structure of the Complex of Human Epidermal Growth Factor and Receptor Extracellular Domains.


Contents

Overview

Epidermal growth factor (EGF) regulates cell proliferation and differentiation by binding to the EGF receptor (EGFR) extracellular region, comprising domains I-IV, with the resultant dimerization of the receptor tyrosine kinase. In this study, the crystal structure of a 2:2 complex of human EGF and the EGFR extracellular region has been determined at 3.3 A resolution. EGFR domains I-III are arranged in a C shape, and EGF is docked between domains I and III. The 1:1 EGF*EGFR complex dimerizes through a direct receptor*receptor interaction, in which a protruding beta-hairpin arm of each domain II holds the body of the other. The unique "receptor-mediated dimerization" was verified by EGFR mutagenesis.

Disease

Known diseases associated with this structure: Adenocarcinoma of lung, response to tyrosine kinase inhibitor in OMIM:[131550], Hypomagnesemia 4, renal OMIM:[131530], Nonsmall cell lung cancer, response to tyrosine kinase inhibitor in OMIM:[131550], Nonsmall cell lung cancer, susceptibility to OMIM:[131550]

About this Structure

1IVO is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of the complex of human epidermal growth factor and receptor extracellular domains., Ogiso H, Ishitani R, Nureki O, Fukai S, Yamanaka M, Kim JH, Saito K, Sakamoto A, Inoue M, Shirouzu M, Yokoyama S, Cell. 2002 Sep 20;110(6):775-87. PMID:12297050

Page seeded by OCA on Thu Mar 20 11:55:30 2008

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