1iwz

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[[Image:1iwz.jpg|left|200px]]<br /><applet load="1iwz" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:1iwz.jpg|left|200px]]
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caption="1iwz, resolution 1.48&Aring;" />
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'''Crystal Structure Analysis of Human lysozyme at 178K.'''<br />
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{{Structure
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|PDB= 1iwz |SIZE=350|CAPTION= <scene name='initialview01'>1iwz</scene>, resolution 1.48&Aring;
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|SITE=
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|LIGAND= <scene name='pdbligand=CL:CHLORIDE ION'>CL</scene>
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|ACTIVITY= [http://en.wikipedia.org/wiki/Lysozyme Lysozyme], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.17 3.2.1.17]
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|GENE=
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}}
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'''Crystal Structure Analysis of Human lysozyme at 178K.'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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1IWZ is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=CL:'>CL</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Lysozyme Lysozyme], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.17 3.2.1.17] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IWZ OCA].
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1IWZ is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IWZ OCA].
==Reference==
==Reference==
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Nonlinear temperature dependence of the crystal structure of lysozyme: correlation between coordinate shifts and thermal factors., Joti Y, Nakasako M, Kidera A, Go N, Acta Crystallogr D Biol Crystallogr. 2002 Sep;58(Pt 9):1421-32. Epub 2002, Aug 23. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=12198298 12198298]
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Nonlinear temperature dependence of the crystal structure of lysozyme: correlation between coordinate shifts and thermal factors., Joti Y, Nakasako M, Kidera A, Go N, Acta Crystallogr D Biol Crystallogr. 2002 Sep;58(Pt 9):1421-32. Epub 2002, Aug 23. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12198298 12198298]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Lysozyme]]
[[Category: Lysozyme]]
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[[Category: o-glycosyl]]
[[Category: o-glycosyl]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 13:16:30 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 11:56:03 2008''

Revision as of 09:56, 20 March 2008

Image:1iwz.jpg


PDB ID 1iwz

Drag the structure with the mouse to rotate
, resolution 1.48Å
Ligands:
Activity: Lysozyme, with EC number 3.2.1.17
Coordinates: save as pdb, mmCIF, xml



Crystal Structure Analysis of Human lysozyme at 178K.


Contents

Overview

The static and dynamic structures of human lysozyme at seven different temperatures ranging from 113 to 178 K were investigated by normal-mode refinement of the cryogenic X-ray diffraction data collected from a single crystal. Normal-mode refinement decomposes the mean-square fluctuations of protein atoms from their average position into the contributions from the internal degrees of freedom, which change the shape of the protein structure, and those from the external degrees of freedom, which generate rigid-body motions in the crystal. While at temperatures below 150 K the temperature dependence of the total mean-square fluctuations shows a small gradient similar to that predicted theoretically by normal-mode analysis, at temperatures above 150 K there is an apparent inflection in the temperature dependence with a higher gradient. The inflection in the temperature dependence at temperatures above 150 K occurs mostly in the external degrees of freedom. Possible causes for the dynamic transition are discussed with respect to the crystal packing and physicochemical properties of crystalline water.

Disease

Known diseases associated with this structure: Amyloidosis, renal OMIM:[153450], Microphthalmia, syndromic 1 OMIM:[309800]

About this Structure

1IWZ is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Nonlinear temperature dependence of the crystal structure of lysozyme: correlation between coordinate shifts and thermal factors., Joti Y, Nakasako M, Kidera A, Go N, Acta Crystallogr D Biol Crystallogr. 2002 Sep;58(Pt 9):1421-32. Epub 2002, Aug 23. PMID:12198298

Page seeded by OCA on Thu Mar 20 11:56:03 2008

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