3c6r

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[[Image:3c6r.png|left|200px]]
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==Low pH Immature Dengue Virus==
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<StructureSection load='3c6r' size='340' side='right' caption='[[3c6r]], [[Resolution|resolution]] 25.00&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3c6r]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Dengue_virus_2_thailand/puo-218/1980 Dengue virus 2 thailand/puo-218/1980]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3C6R OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3C6R FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3c6r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3c6r OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3c6r RCSB], [http://www.ebi.ac.uk/pdbsum/3c6r PDBsum]</span></td></tr>
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<table>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/c6/3c6r_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Intracellular cleavage of immature flaviviruses is a critical step in assembly that generates the membrane fusion potential of the E glycoprotein. With cryo-electron microscopy we show that the immature dengue particles undergo a reversible conformational change at low pH that renders them accessible to furin cleavage. At a pH of 6.0, the E proteins are arranged in a herringbone pattern with the pr peptides docked onto the fusion loops, a configuration similar to that of the mature virion. After cleavage, the dissociation of pr is pH-dependent, suggesting that in the acidic environment of the trans-Golgi network pr is retained on the virion to prevent membrane fusion. These results suggest a mechanism by which flaviviruses are processed and stabilized in the host cell secretory pathway.
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{{STRUCTURE_3c6r| PDB=3c6r | SCENE= }}
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Structure of the immature dengue virus at low pH primes proteolytic maturation.,Yu IM, Zhang W, Holdaway HA, Li L, Kostyuchenko VA, Chipman PR, Kuhn RJ, Rossmann MG, Chen J Science. 2008 Mar 28;319(5871):1834-7. PMID:18369148<ref>PMID:18369148</ref>
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===Low pH Immature Dengue Virus===
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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{{ABSTRACT_PUBMED_18369148}}
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== References ==
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<references/>
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==About this Structure==
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__TOC__
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[[3c6r]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Dengue_virus_2 Dengue virus 2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3C6R OCA].
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</StructureSection>
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[[Category: Dengue virus 2 thailand/puo-218/1980]]
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==Reference==
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<ref group="xtra">PMID:018369148</ref><references group="xtra"/>
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[[Category: Dengue virus 2]]
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[[Category: Chen, J.]]
[[Category: Chen, J.]]
[[Category: Chipman, P R.]]
[[Category: Chipman, P R.]]

Revision as of 21:37, 2 October 2014

Low pH Immature Dengue Virus

3c6r, resolution 25.00Å

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OCA

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