1usx

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{{STRUCTURE_1usx| PDB=1usx | SCENE= }}
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==Crystal structure of the Newcastle disease virus hemagglutinin-neuraminidase complexed with thiosialoside==
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===Crystal structure of the Newcastle disease virus hemagglutinin-neuraminidase complexed with thiosialoside===
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<StructureSection load='1usx' size='340' side='right' caption='[[1usx]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
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{{ABSTRACT_PUBMED_15016893}}
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1usx]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Avian_paramyxovirus_type_1 Avian paramyxovirus type 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1USX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1USX FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DAN:2-DEOXY-2,3-DEHYDRO-N-ACETYL-NEURAMINIC+ACID'>DAN</scene>, <scene name='pdbligand=SIA:O-SIALIC+ACID'>SIA</scene>, <scene name='pdbligand=WIA:METHYL(6S)-1-THIO-L-MANNO-HEXODIALDO-6,2-PYRANOSIDE'>WIA</scene><br>
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<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1e8t|1e8t]], [[1e8u|1e8u]], [[1e8v|1e8v]], [[1usr|1usr]]</td></tr>
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<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Exo-alpha-sialidase Exo-alpha-sialidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.18 3.2.1.18] </span></td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1usx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1usx OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1usx RCSB], [http://www.ebi.ac.uk/pdbsum/1usx PDBsum]</span></td></tr>
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<table>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/us/1usx_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Paramyxoviruses are the leading cause of respiratory disease in children. Several paramyxoviruses possess a surface glycoprotein, the hemagglutinin-neuraminidase (HN), that is involved in attachment to sialic acid receptors, promotion of fusion, and removal of sialic acid from infected cells and progeny virions. Previously we showed that Newcastle disease virus (NDV) HN contained a pliable sialic acid recognition site that could take two states, a binding state and a catalytic state. Here we present evidence for a second sialic acid binding site at the dimer interface of HN and present a model for its involvement in cell fusion. Three different crystal forms of NDV HN now reveal identical tetrameric arrangements of HN monomers, perhaps indicative of the tetramer association found on the viral surface.
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==Function==
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Second sialic acid binding site in Newcastle disease virus hemagglutinin-neuraminidase: implications for fusion.,Zaitsev V, von Itzstein M, Groves D, Kiefel M, Takimoto T, Portner A, Taylor G J Virol. 2004 Apr;78(7):3733-41. PMID:15016893<ref>PMID:15016893</ref>
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[[http://www.uniprot.org/uniprot/HN_NDVB HN_NDVB]] Attaches the virus to sialic acid-containing cell receptors and thereby initiating infection. Binding of HN protein to the receptor induces a conformational change that allows the F protein to trigger virion/cell membranes fusion (By similarity). Neuraminidase activity ensures the efficient spread of the virus by dissociating the mature virions from the neuraminic acid containing glycoproteins (By similarity).
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==About this Structure==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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[[1usx]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Avian_paramyxovirus_type_1 Avian paramyxovirus type 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1USX OCA].
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</div>
==See Also==
==See Also==
*[[Hemagglutinin|Hemagglutinin]]
*[[Hemagglutinin|Hemagglutinin]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:015016893</ref><references group="xtra"/><references/>
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__TOC__
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</StructureSection>
[[Category: Avian paramyxovirus type 1]]
[[Category: Avian paramyxovirus type 1]]
[[Category: Exo-alpha-sialidase]]
[[Category: Exo-alpha-sialidase]]

Revision as of 05:18, 3 October 2014

Crystal structure of the Newcastle disease virus hemagglutinin-neuraminidase complexed with thiosialoside

1usx, resolution 2.70Å

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