1upx

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{{STRUCTURE_1upx| PDB=1upx | SCENE= }}
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==THE CRYSTAL STRUCTURE OF THE HYBRID CLUSTER PROTEIN FROM DESULFOVIBRIO DESULFURICANS CONTAINING MOLECULES IN THE OXIDIZED AND REDUCED STATES.==
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===THE CRYSTAL STRUCTURE OF THE HYBRID CLUSTER PROTEIN FROM DESULFOVIBRIO DESULFURICANS CONTAINING MOLECULES IN THE OXIDIZED AND REDUCED STATES.===
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<StructureSection load='1upx' size='340' side='right' caption='[[1upx]], [[Resolution|resolution]] 1.25&Aring;' scene=''>
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{{ABSTRACT_PUBMED_14646063}}
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1upx]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Desulfovibrio_desulfuricans Desulfovibrio desulfuricans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UPX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1UPX FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FSO:IRON/SULFUR/OXYGEN+HYBRID+CLUSTER'>FSO</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene>, <scene name='pdbligand=SF3:FE4-S3+CLUSTER'>SF3</scene>, <scene name='pdbligand=SF4:IRON/SULFUR+CLUSTER'>SF4</scene><br>
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<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1gn9|1gn9]], [[1gnl|1gnl]], [[1oa0|1oa0]]</td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1upx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1upx OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1upx RCSB], [http://www.ebi.ac.uk/pdbsum/1upx PDBsum]</span></td></tr>
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<table>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/up/1upx_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The hybrid cluster protein (HCP) from the sulfate-reducing bacteria Desulfovibrio desulfuricans ATCC 27774 has been isolated and crystallized anaerobically. The protein sample used in the crystallization studies was several months old, having been stored at 193 K, and initial crystal structure studies were unable to fully resolve details of the hybrid cluster despite the use of high-resolution data to 1.25 A collected at the ESRF, Grenoble, France. Full elucidation of the structure has only become possible with the complete knowledge of the as-isolated and fully reduced crystal structures. The analysis clarifies the significant movements in the position of the Fe atom linked to the persulfide moiety in the oxidized as-isolated protein and the S atom of the persulfide itself as the protein is reduced. The structures of the as-isolated and reduced states are discussed in terms of the putative function of the HCP proteins.
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==Function==
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Structure of the hybrid cluster protein (HCP) from Desulfovibrio desulfuricans ATCC 27774 containing molecules in the oxidized and reduced states.,Macedo S, Aragao D, Mitchell EP, Lindley P Acta Crystallogr D Biol Crystallogr. 2003 Dec;59(Pt 12):2065-71. Epub 2003, Nov 27. PMID:14646063<ref>PMID:14646063</ref>
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[[http://www.uniprot.org/uniprot/HCP_DESDE HCP_DESDE]] Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O (By similarity).[HAMAP-Rule:MF_00069]
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==About this Structure==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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[[1upx]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Desulfovibrio_desulfuricans Desulfovibrio desulfuricans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UPX OCA].
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</div>
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:014646063</ref><references group="xtra"/><references/>
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__TOC__
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</StructureSection>
[[Category: Desulfovibrio desulfuricans]]
[[Category: Desulfovibrio desulfuricans]]
[[Category: Aragao, D.]]
[[Category: Aragao, D.]]

Revision as of 08:27, 3 October 2014

THE CRYSTAL STRUCTURE OF THE HYBRID CLUSTER PROTEIN FROM DESULFOVIBRIO DESULFURICANS CONTAINING MOLECULES IN THE OXIDIZED AND REDUCED STATES.

1upx, resolution 1.25Å

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