1q42

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{{STRUCTURE_1q42| PDB=1q42 | SCENE= }}
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==Crystal structure analysis of the Candida albicans Mtr2==
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===Crystal structure analysis of the Candida albicans Mtr2===
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<StructureSection load='1q42' size='340' side='right' caption='[[1q42]], [[Resolution|resolution]] 1.75&Aring;' scene=''>
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{{ABSTRACT_PUBMED_14504280}}
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1q42]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Candida_albicans Candida albicans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Q42 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1Q42 FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1of5|1of5]], [[1q40|1q40]]</td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1q42 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1q42 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1q42 RCSB], [http://www.ebi.ac.uk/pdbsum/1q42 PDBsum]</span></td></tr>
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<table>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/q4/1q42_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The formation of the Mtr2-Mex67 heterodimer is essential for yeast mRNA export as it constitutes a key nuclear component for shuttling mRNA between the nuclear and cytoplasm compartments through the nuclear pore complex. We report the crystal structures of apo-Mtr2 from the human pathogen Candida albicans and of its complex with the Mex67 NTF2-like domain. Compared with other members of the NTF2 fold family, Mtr2 displays novel structural features involved in the nuclear export of the large ribosomal subunit and consistent with a dual functional role of Mtr2 during yeast nuclear export events. The structure of the Mtr2-Mex67 NTF2-like domain complex, which overall is similar to those of the human and Saccharomyces cerevisiae homologs, unveils three putative Phe-Gly repeat binding sites, of which one contributes to the heterodimer interface. These structures exemplify an unrecognized adaptability of the NTF2 building block in evolution, identify novel structural determinants associated with key biological functions at the molecular surface of the yeast Mtr2-Mex67 complex, and suggest that the yeast and human mRNA export machineries may differ.
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==Function==
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The Mtr2-Mex67 NTF2-like domain complex. Structural insights into a dual role of Mtr2 for yeast nuclear export.,Senay C, Ferrari P, Rocher C, Rieger KJ, Winter J, Platel D, Bourne Y J Biol Chem. 2003 Nov 28;278(48):48395-403. Epub 2003 Sep 22. PMID:14504280<ref>PMID:14504280</ref>
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[[http://www.uniprot.org/uniprot/MTR2_CANAL MTR2_CANAL]] Affects mRNA transport from the nucleus to the cytoplasm.
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==About this Structure==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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[[1q42]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Candida_albicans Candida albicans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Q42 OCA].
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</div>
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:014504280</ref><references group="xtra"/><references/>
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__TOC__
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</StructureSection>
[[Category: Candida albicans]]
[[Category: Candida albicans]]
[[Category: Bourne, Y.]]
[[Category: Bourne, Y.]]

Revision as of 09:45, 3 October 2014

Crystal structure analysis of the Candida albicans Mtr2

1q42, resolution 1.75Å

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