1j7v
From Proteopedia
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| - | [[Image:1j7v.jpg|left|200px]] | + | [[Image:1j7v.jpg|left|200px]] |
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| - | '''HUMAN IL-10 / IL-10R1 COMPLEX''' | + | {{Structure |
| + | |PDB= 1j7v |SIZE=350|CAPTION= <scene name='initialview01'>1j7v</scene>, resolution 2.9Å | ||
| + | |SITE= | ||
| + | |LIGAND= | ||
| + | |ACTIVITY= | ||
| + | |GENE= | ||
| + | }} | ||
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| + | '''HUMAN IL-10 / IL-10R1 COMPLEX''' | ||
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==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1J7V is a [ | + | 1J7V is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1J7V OCA]. |
==Reference== | ==Reference== | ||
| - | Crystal structure of the IL-10/IL-10R1 complex reveals a shared receptor binding site., Josephson K, Logsdon NJ, Walter MR, Immunity. 2001 Jul;15(1):35-46. PMID:[http:// | + | Crystal structure of the IL-10/IL-10R1 complex reveals a shared receptor binding site., Josephson K, Logsdon NJ, Walter MR, Immunity. 2001 Jul;15(1):35-46. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11485736 11485736] |
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Protein complex]] | [[Category: Protein complex]] | ||
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[[Category: interleukin-10]] | [[Category: interleukin-10]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 11:59:50 2008'' |
Revision as of 09:59, 20 March 2008
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| , resolution 2.9Å | |||||||
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| Coordinates: | save as pdb, mmCIF, xml | ||||||
HUMAN IL-10 / IL-10R1 COMPLEX
Contents |
Overview
Interleukin 10 (IL-10) is a dimeric cytokine that plays a central role in suppressing inflammatory responses. These activities are dependent on the interaction of IL-10 with its high-affinity receptor (IL-10R1). This intermediate complex must subsequently recruit the low-affinity IL-10R2 chain before cell signaling can occur. Here we report the 2.9 A crystal structure of IL-10 bound to a soluble form of IL-10R1 (sIL-10R1). The complex consists of two IL-10s and four sIL-10R1 molecules. Several residues in the IL-10/sIL-10R1 interface are conserved in all IL-10 homologs and their receptors. The data suggests that formation of the active IL-10 signaling complex occurs by a novel molecular recognition paradigm where IL-10R1 and IL-10R2 both recognize the same binding site on IL-10.
Disease
Known diseases associated with this structure: Graft-versus-host disease, protection against OMIM:[124092], HIV-1, susceptibility to OMIM:[124092], Rheumatoid arthritis, progression of OMIM:[124092]
About this Structure
1J7V is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Crystal structure of the IL-10/IL-10R1 complex reveals a shared receptor binding site., Josephson K, Logsdon NJ, Walter MR, Immunity. 2001 Jul;15(1):35-46. PMID:11485736
Page seeded by OCA on Thu Mar 20 11:59:50 2008
