1j9k

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[[Image:1j9k.jpg|left|200px]]<br /><applet load="1j9k" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:1j9k.jpg|left|200px]]
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caption="1j9k, resolution 2.10&Aring;" />
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'''CRYSTAL STRUCTURE OF SURE PROTEIN FROM T.MARITIMA IN COMPLEX WITH TUNGSTATE'''<br />
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{{Structure
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|PDB= 1j9k |SIZE=350|CAPTION= <scene name='initialview01'>1j9k</scene>, resolution 2.10&Aring;
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|SITE=
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|LIGAND= <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=WO4:TUNGSTATE(VI)ION'>WO4</scene> and <scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID'>EPE</scene>
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|ACTIVITY=
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|GENE=
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}}
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'''CRYSTAL STRUCTURE OF SURE PROTEIN FROM T.MARITIMA IN COMPLEX WITH TUNGSTATE'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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1J9K is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Thermotoga_maritima Thermotoga maritima] with <scene name='pdbligand=CA:'>CA</scene>, <scene name='pdbligand=WO4:'>WO4</scene> and <scene name='pdbligand=EPE:'>EPE</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1J9K OCA].
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1J9K is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Thermotoga_maritima Thermotoga maritima]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1J9K OCA].
==Reference==
==Reference==
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Crystal structure and functional analysis of the SurE protein identify a novel phosphatase family., Lee JY, Kwak JE, Moon J, Eom SH, Liong EC, Pedelacq JD, Berendzen J, Suh SW, Nat Struct Biol. 2001 Sep;8(9):789-94. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=11524683 11524683]
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Crystal structure and functional analysis of the SurE protein identify a novel phosphatase family., Lee JY, Kwak JE, Moon J, Eom SH, Liong EC, Pedelacq JD, Berendzen J, Suh SW, Nat Struct Biol. 2001 Sep;8(9):789-94. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11524683 11524683]
[[Category: Single protein]]
[[Category: Single protein]]
[[Category: Thermotoga maritima]]
[[Category: Thermotoga maritima]]
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[[Category: tungstate complex]]
[[Category: tungstate complex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 13:20:09 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 12:00:23 2008''

Revision as of 10:00, 20 March 2008

Image:1j9k.jpg


PDB ID 1j9k

Drag the structure with the mouse to rotate
, resolution 2.10Å
Ligands: , and
Coordinates: save as pdb, mmCIF, xml



CRYSTAL STRUCTURE OF SURE PROTEIN FROM T.MARITIMA IN COMPLEX WITH TUNGSTATE


Overview

Homologs of the Escherichia coli surE gene are present in many eubacteria and archaea. Despite the evolutionary conservation, little information is available on the structure and function of their gene products. We have determined the crystal structure of the SurE protein from Thermotoga maritima. The structure reveals the dimeric arrangement of the subunits and an active site around a bound metal ion. We also demonstrate that the SurE protein exhibits a divalent metal ion-dependent phosphatase activity that is inhibited by vanadate or tungstate. In the vanadate- and tungstate-complexed structures, the inhibitors bind adjacent to the divalent metal ion. Our structural and functional analyses identify the SurE proteins as a novel family of metal ion-dependent phosphatases.

About this Structure

1J9K is a Single protein structure of sequence from Thermotoga maritima. Full crystallographic information is available from OCA.

Reference

Crystal structure and functional analysis of the SurE protein identify a novel phosphatase family., Lee JY, Kwak JE, Moon J, Eom SH, Liong EC, Pedelacq JD, Berendzen J, Suh SW, Nat Struct Biol. 2001 Sep;8(9):789-94. PMID:11524683

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