1tap

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[[Image:1tap.png|left|200px]]
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==NMR SOLUTION STRUCTURE OF RECOMBINANT TICK ANTICOAGULANT PROTEIN (RTAP), A FACTOR XA INHIBITOR FROM THE TICK ORNITHODOROS MOUBATA==
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<StructureSection load='1tap' size='340' side='right' caption='[[1tap]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1tap]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Ornithodoros_moubata Ornithodoros moubata]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TAP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1TAP FirstGlance]. <br>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1tap FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tap OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1tap RCSB], [http://www.ebi.ac.uk/pdbsum/1tap PDBsum]</span></td></tr>
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</table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The solution structure of the recombinant tick anticoagulant protein (rTAP) was determined by 1H nuclear magnetic resonance (NMR) spectroscopy in aqueous solution at pH 3.6 and 36 degrees C. rTAP is a 60-residue protein functioning as a highly specific inhibitor of the coagulation protease factor Xa, which was originally isolated from the tick Ornithodoros moubata. Its regular secondary structure consists of a two-stranded antiparallel beta-sheet with residues 22-28 and 32-38, and an alpha-helix with residues 51-60. The relative orientation of these regular secondary structure elements has nearly identical counterparts in the bovine pancreatic trypsin inhibitor (BPTI). In contrast, the loop between the beta-sheet and the C-terminal alpha-helix as well as the N-terminal 20-residue segment preceding the beta-sheet adopt different three-dimensional folds in the two proteins. These observations are discussed with regard to the implication of different mechanisms of protease inhibition by rTAP and by Kunitz-type protein proteinase inhibitors.
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{{STRUCTURE_1tap| PDB=1tap | SCENE= }}
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NMR solution structure of the recombinant tick anticoagulant protein (rTAP), a factor Xa inhibitor from the tick Ornithodoros moubata.,Antuch W, Guntert P, Billeter M, Hawthorne T, Grossenbacher H, Wuthrich K FEBS Lett. 1994 Sep 26;352(2):251-7. PMID:7925983<ref>PMID:7925983</ref>
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===NMR SOLUTION STRUCTURE OF RECOMBINANT TICK ANTICOAGULANT PROTEIN (RTAP), A FACTOR XA INHIBITOR FROM THE TICK ORNITHODOROS MOUBATA===
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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{{ABSTRACT_PUBMED_7925983}}
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== References ==
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<references/>
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==About this Structure==
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__TOC__
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[[1tap]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Ornithodoros_moubata Ornithodoros moubata]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TAP OCA].
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</StructureSection>
[[Category: Ornithodoros moubata]]
[[Category: Ornithodoros moubata]]
[[Category: Antuch, W.]]
[[Category: Antuch, W.]]

Revision as of 08:17, 8 October 2014

NMR SOLUTION STRUCTURE OF RECOMBINANT TICK ANTICOAGULANT PROTEIN (RTAP), A FACTOR XA INHIBITOR FROM THE TICK ORNITHODOROS MOUBATA

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