1qxb

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[[Image:1qxb.png|left|200px]]
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==NMR structure determination of the self complementary DNA Dodecamer CGCGAATT*CGCG in which a ribose is inserted between the 3'-OH of T8 and the 5'-phosphate group of C9==
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<StructureSection load='1qxb' size='340' side='right' caption='[[1qxb]], [[NMR_Ensembles_of_Models | 1 NMR models]]' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1qxb]] is a 2 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QXB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1QXB FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BDR:BETA-D-RIBOFURANOSYL'>BDR</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1qxb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qxb OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1qxb RCSB], [http://www.ebi.ac.uk/pdbsum/1qxb PDBsum]</span></td></tr>
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</table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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A ribose residue inserted between the 3'-OH of one nucleotide and the 5'-phosphate group of the next nucleotide, functions as a site-specific cleavage site within DNA. This extra ribose does not interrupt helix formation and it protects duplex DNA against cleavage by restriction enzymes. Cleavage can be obtained with periodate and all ribose fragments can be removed with sodium hydroxide. As a result of this, an intact natural oligodeoxynucleotide is obtained after ligation reaction, which means that site-specific cleavage and recovering of intact DNA occurs without loss of genetic information.
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{{STRUCTURE_1qxb| PDB=1qxb | SCENE= }}
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Cleavage of DNA without loss of genetic information by incorporation of a disaccharide nucleoside.,Nauwelaerts K, Vastmans K, Froeyen M, Kempeneers V, Rozenski J, Rosemeyer H, Van Aerschot A, Busson R, Lacey JC, Efimtseva E, Mikhailov S, Lescrinier E, Herdewijn P Nucleic Acids Res. 2003 Dec 1;31(23):6758-69. PMID:14627809<ref>PMID:14627809</ref>
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===NMR structure determination of the self complementary DNA Dodecamer CGCGAATT*CGCG in which a ribose is inserted between the 3'-OH of T8 and the 5'-phosphate group of C9===
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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{{ABSTRACT_PUBMED_14627809}}
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== References ==
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<references/>
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==About this Structure==
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__TOC__
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[[1qxb]] is a 2 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QXB OCA].
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</StructureSection>
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==Reference==
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<ref group="xtra">PMID:014627809</ref><references group="xtra"/>
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[[Category: Aerschot, A Van.]]
[[Category: Aerschot, A Van.]]
[[Category: Busson, R.]]
[[Category: Busson, R.]]

Revision as of 08:19, 8 October 2014

NMR structure determination of the self complementary DNA Dodecamer CGCGAATT*CGCG in which a ribose is inserted between the 3'-OH of T8 and the 5'-phosphate group of C9

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