1yo4

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[[Image:1yo4.png|left|200px]]
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==Solution Structure of the SARS Coronavirus ORF 7a coded X4 protein==
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<StructureSection load='1yo4' size='340' side='right' caption='[[1yo4]], [[NMR_Ensembles_of_Models | 10 NMR models]]' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1yo4]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Sars_coronavirus Sars coronavirus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YO4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1YO4 FirstGlance]. <br>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1yo4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1yo4 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1yo4 RCSB], [http://www.ebi.ac.uk/pdbsum/1yo4 PDBsum]</span></td></tr>
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</table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The SARS related Coronavirus genome contains a variety of novel accessory genes. One of these, called ORF7a or ORF8, code for a protein, known as 7a, U122 or X4. We set out to determine the three-dimensional structure of the soluble ectodomain of this type-I transmembrane protein by nuclear magnetic resonance spectroscopy. The fold of the protein is the first member of a further variation of the immunoglobulin like beta-sandwich fold. Because X4 does not reveal significant sequence homologies to proteins in the data bases, we carried out a structure based similarity search for proteins with known function. High structural similarity to Dl domains of ICAM-1 and ICAM-2, and common features in amino acid sequence between X4 and ICAM-1, suggest X4 to possess binding activity for the alpha(L) integrin I domain of LFA-1. Further, based on this structure based prediction, potential functions of X4 in virus replication and pathogenesis are discussed.
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{{STRUCTURE_1yo4| PDB=1yo4 | SCENE= }}
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Solution structure of the X4 protein coded by the SARS related coronavirus reveals an immunoglobulin like fold and suggests a binding activity to integrin I domains.,Hanel K, Stangler T, Stoldt M, Willbold D J Biomed Sci. 2006 May;13(3):281-93. Epub 2005 Nov 23. PMID:16328780<ref>PMID:16328780</ref>
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===Solution Structure of the SARS Coronavirus ORF 7a coded X4 protein===
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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{{ABSTRACT_PUBMED_16328780}}
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== References ==
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<references/>
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==About this Structure==
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__TOC__
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[[1yo4]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Sars_coronavirus Sars coronavirus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YO4 OCA].
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</StructureSection>
[[Category: Sars coronavirus]]
[[Category: Sars coronavirus]]
[[Category: Haenel, K.]]
[[Category: Haenel, K.]]

Revision as of 08:32, 8 October 2014

Solution Structure of the SARS Coronavirus ORF 7a coded X4 protein

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