1p58

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[[Image:1p58.png|left|200px]]
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==Complex Organization of Dengue Virus Membrane Proteins as Revealed by 9.5 Angstrom Cryo-EM reconstruction==
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<StructureSection load='1p58' size='340' side='right' caption='[[1p58]], [[Resolution|resolution]] 9.50&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1p58]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Dengue_virus_2_puerto_rico/pr159-s1/1969 Dengue virus 2 puerto rico/pr159-s1/1969]. The July 2008 RCSB PDB [http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Dengue Virus'' by David Goodsell is [http://dx.doi.org/10.2210/rcsb_pdb/mom_2008_7 10.2210/rcsb_pdb/mom_2008_7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1P58 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1P58 FirstGlance]. <br>
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1k4r|1k4r]], [[1svb|1svb]], [[1jch|1jch]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1p58 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1p58 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1p58 RCSB], [http://www.ebi.ac.uk/pdbsum/1p58 PDBsum]</span></td></tr>
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</table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Improved technology for reconstructing cryo-electron microscopy (cryo-EM) images has now made it possible to determine secondary structural features of membrane proteins in enveloped viruses. The structure of mature dengue virus particles was determined to a resolution of 9.5 A by cryo-EM and image reconstruction techniques, establishing the secondary structural disposition of the 180 envelope (E) and 180 membrane (M) proteins in the lipid envelope. The alpha-helical 'stem' regions of the E molecules, as well as part of the N-terminal section of the M proteins, are buried in the outer leaflet of the viral membrane. The 'anchor' regions of E and the M proteins each form antiparallel E-E and M-M transmembrane alpha-helices, leaving their C termini on the exterior of the viral membrane, consistent with the predicted topology of the unprocessed polyprotein. This is one of only a few determinations of the disposition of transmembrane proteins in situ and shows that the nucleocapsid core and envelope proteins do not have a direct interaction in the mature virus.
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{{STRUCTURE_1p58| PDB=1p58 | SCENE= }}
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Visualization of membrane protein domains by cryo-electron microscopy of dengue virus.,Zhang W, Chipman PR, Corver J, Johnson PR, Zhang Y, Mukhopadhyay S, Baker TS, Strauss JH, Rossmann MG, Kuhn RJ Nat Struct Biol. 2003 Nov;10(11):907-12. Epub 2003 Oct 5. PMID:14528291<ref>PMID:14528291</ref>
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===Complex Organization of Dengue Virus Membrane Proteins as Revealed by 9.5 Angstrom Cryo-EM reconstruction===
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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{{ABSTRACT_PUBMED_14528291}}
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== References ==
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<references/>
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==About this Structure==
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__TOC__
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[[1p58]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Viruses Viruses]. The July 2008 RCSB PDB [http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Dengue Virus'' by David Goodsell is [http://dx.doi.org/10.2210/rcsb_pdb/mom_2008_7 10.2210/rcsb_pdb/mom_2008_7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1P58 OCA].
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</StructureSection>
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==Reference==
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<ref group="xtra">PMID:014528291</ref><references group="xtra"/>
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[[Category: Dengue Virus]]
[[Category: Dengue Virus]]
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[[Category: Dengue virus 2 puerto rico/pr159-s1/1969]]
[[Category: RCSB PDB Molecule of the Month]]
[[Category: RCSB PDB Molecule of the Month]]
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[[Category: Viruses]]
 
[[Category: Baker, T S.]]
[[Category: Baker, T S.]]
[[Category: Chipman, P R.]]
[[Category: Chipman, P R.]]

Revision as of 08:33, 8 October 2014

Complex Organization of Dengue Virus Membrane Proteins as Revealed by 9.5 Angstrom Cryo-EM reconstruction

1p58, resolution 9.50Å

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